Robinette Foundation Professor of Cardiovascular Medicine, Professor of Pathology and Laboratory Medicine, and Professor of
Professor, IME & Department of Pathology and Laboratory Medicine
1010 Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104-6383
(215) 898-4647, phone
(215) 573-6815, fax
PhD, Experimental Pathology 1975 – Cambridge University UK
Honors and Awards
Special Dean’s Award – School of Medicine – 2010, Senior Research Scientist Award – American Heart Association – 2004
Peter’s bioengineering research is directed at the fundamental mechanisms underlying cardiovascular diseases, in particular, the cellular, subcellular, and molecular pathophysiology of endothelial cells and the role that hemodynamics plays in the epigenetic regulation of molecular mechanotransduction, gene and protein expression an functional consequences in health and disease. Peter and his lab use computational models, experimental in vivo and in vitro flow devices and a full range of cell and molecular biology approaches.
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics andcomputational fluid dynamics. Stent design.
Hayward JS, Davies PF. Evidence for the mediatory role of brown adipose tissue during nonshivering thermogenesis in the cold-acclimated mouse. Can J Physiol Pharmacol Feb 1972; 50 (2): 168-170.
Davies PF, Bowyer DE. Scanning electron microscopy: arterial endothelial integrity after fixation at physiological pressure. Atherosclerosis May-Jun 1975; 21 (3): 463-469.
Davies PF, Reidy MA, Goode TB, Bowyer DE. Scanning electron microscopy in the evaluation of endothelial integrity of the fatty lesion in atherosclerosis. Atherosclerosis Oct 1976; 25 (1): 125-130.
Bowyer DE, Davies PF, Reidy MA, Goode TB, Green ES. Scanning electron microscopy of arterial endothelium. Prog Biochem Pharmacol 1977; 13 164-170.
Davies PF, Bowyer DE. Evidence for two metabolic pools of arterial cholesteryl esters in developing experimental atherosclerosis in the rabbit. Biochem Soc Trans 1977; 5 (1): 134-136.
Goode TB, Davies PF, Reidy MA, Bowyer DE. Aortic endothelial cell morphology observed in situ by scanning electron microscopy during atherogenesis in the rabbit. Atherosclerosis Jun 1977; 27 (2): 235-251.
Bowyer DE, Davies PF. Effect of concentration of perfusing free fatty acid on arterial lipid synthesis in perfused normal and atherosclerotic rabbit aortas. Atherosclerosis Dec 1978; 31 (4): 409-419.
Davies PF, Ross R. Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor. J Cell Biol Dec 1978; 79 (3): 663-671.
Davies PF, Ross R. Fluid Pinocytosis in Cultured-Cells – Mediation by Growth-Factors and Cell Density. Journal of Cell Biology 1978; 79 (2): A61-A61.
Davies PF. Cell-cell contact and growth regulation of pinocytosis in 3T3 cells. J Supramol Struct 1980; 13 (2): 211-217.
Davies PF. Cell-Cell Contact and Growth-Regulation of Endocytosis in Cultured-Cells. Federation Proceedings 1980; 39 (3): 770-770.
Davies PF, Rennke HG, Cotran RS. Charge-Selective Endocytosis and Intracellular Degradation of Peroxidase in Cultured Arterial Endothelial-Cells. Journal of Cell Biology 1980; 87 (2): A313-A313.
Davies PF, Ross R. Growth-mediated, density-dependent inhibition of endocytosis in cultured arterial smooth muscle cells. Exp Cell Res Oct 1980; 129 (2): 329-336.
Davies PF, Selden SC, 3rd, Schwartz SM. Enhanced rates of fluid pinocytosis during exponential growth and monolayer regeneration by cultured arterial endothelial cells. J Cell Physiol Feb 1980; 102 (2): 119-127.
Davies PF, Selden SC, Schwartz SM. Enhanced Rates of Fluid Pinocytosis during Exponential-Growth and Monolayer Regeneration by Cultured Arterial Endothelial-Cells. Journal of Cellular Physiology 1980; 102 (2): 119-127.
Davies PF. Microcarrier culture of vascular endothelial cells on solid plastic beads. Exp Cell Res Aug 1981; 134 (2): 367-376.
Davies PF. Microcarrier cultures in vascular endothelial research. Dev Biol Stand 1981; 50 125-136.
Davies PF. Growth-Factor Stimulation of Low-Density Lipoprotein Binding to Vascular Cells Is Not Directly Related to the Mitogenic Response. Federation Proceedings 1981; 40 (3): 327-327.
Davies PF, Kuczera L. Endocytic vesicles and surface invaginations in cultured vascular endothelium: a morphometric comparison. J Histochem Cytochem Dec 1981; 29 (12): 1437-1441.
Davies PF, Rennke HG, Cotran RS. Influence of molecular charge upon the endocytosis and intracellular fate of peroxidase activity in cultured arterial endothelium. J Cell Sci Jun 1981; 49 69-86.
Dewey CF, Jr., Bussolari SR, Gimbrone MA, Jr., Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng Aug 1981; 103 (3): 177-185.
Gimbrone MA, Dewey CF, Davies PF, Bussolari SR. Hemodynamic Shear-Stress and Endothelial Cell-Function – Invitro Studies. Thrombosis and Haemostasis 1981; 46 (1): 153-153.
Gimbrone MA, Dewey CF, Davies PF, Bussolari SR, Cruise SA. Effects of Fluid Shear-Stress on Vascular Endothelial-Cells – Invitro Studies. Federation Proceedings 1981; 40 (3): 327-327.
Davies PF, Kerr C. Co-cultivation of vascular endothelial and smooth muscle cells using microcarrier techniques. Exp Cell Res Oct 1982; 141 (2): 455-459.
Davies PF, Kerr C. Modification of low density lipoprotein metabolism by growth factors in cultured vascular cells and human skin fibroblasts. Dependence upon duration of exposure. Biochim Biophys Acta Jul 20 1982; 712 (1): 26-32.
Davies PF, Kerr C, Eisenhaure B. Co-Cultivation of Vascular Cells – Endothelial-Specific Stimulation of Low-Density Lipoprotein (Ldl) Metabolism in Arterial Smooth-Muscle Cells. Federation Proceedings 1982; 41 (3): 269-269.
Davies PF, Rennke HG, Thomason CL, Mendrick DL, Schilero G. Antibodies That Inhibit Clathrin Binding to a Cytosol-Facting Receptor on Decoated Vesicles. Journal of Cell Biology 1983; 97 (5): A175-A175.
Warren HB, Oconnor SE, Eisenhaure BM, Davies PF. Co-Culture of Vascular Endothelium and Smooth-Muscle Cells – Effects of Heparin on Smooth-Muscle Proliferation. Journal of Cell Biology 1983; 97 (5): A87-A87.
Davies PF, Dewey CF, Jr., Bussolari SR, Gordon EJ, Gimbrone MA, Jr. Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells. J Clin Invest Apr 1984; 73 (4): 1121-1129.
Remuzzi A, Dewey CF, Jr., Davies PF, Gimbrone MA, Jr. Orientation of endothelial cells in shear fields in vitro. Biorheology 1984; 21 (4): 617-630.
Truskey GA, Colton CK, Davies PF. Kinetic-Analysis of Receptor-Mediated Endocytosis and Lysosomal Degradation in Cultured-Cells. Annals of the New York Academy of Sciences 1984; 435 (Dec): 349-351.
Darton KP, Davies PF. Computerized Inventory of Test Articles in Toxicology. Medical Informatics 1985; 10 (2): 183-184.
Davies PF. Current concepts of vascular endothelial and smooth muscle cell communication. Surv Synth Pathol Res 1985; 4 (5-6): 357-373.
Davies PF, Ganz P, Diehl PS. Reversible microcarrier-mediated junctional communication between endothelial and smooth muscle cell monolayers: an in vitro model of vascular cell interactions. Lab Invest Dec 1985; 53 (6): 710-718.
Davies PF, Ganz P, Diehl PS. Methods in Laboratory Investigation – Reversible Microcarrier-Mediated Junctional Communication between Endothelial and Smooth-Muscle Cell Monolayers – an Invitro Model of Vascular Cell-Interactions. Laboratory Investigation 1985; 53 (6): 710-718.
Davies PF, Remuzzi A, Gimbrone MA, Dewey CF. Enhanced Endothelial-Cell Turnover Is Caused by Turbulent Fluid Shear-Stress. Clinical Hemorheology 1985; 5 (5): 650-650.
Davies PF, Rennke HG, Mendrick DL, Thomason CL, Schilero G. Intracellular Probes of Endothelial Vesicle Traffic. Federation Proceedings 1985; 44 (4): 908-908.
Davies PF, Shevland JE. Superior vena caval obstruction: an analysis of seventy-six cases, with comments on the safety of venography. Angiology Jun 1985; 36 (6): 354-357.
Davies PF, Truskey GA, Warren HB, O’Connor SE, Eisenhaure BH. Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. J Cell Biol Sep 1985; 101 (3): 871-879.
Diehl P, Davies PF. Microcarrier-Mediated Junctional Contact between Endothelial-Cells and Smooth-Muscle Cells – an Invitro Model of Vascular Cell-Interactions. Federation Proceedings 1985; 44 (4): 1134-1134.
Ganz P, Davies PF, Leopold JA, Gimbrone MA, Alexander RW. Endothelial-Vascular Smooth-Muscle Interaction in Culture. Circulation 1985; 72 (4): 265-265.
Truskey GA, Davies PF. Effects of ammonium ion derived from bovine endothelial cells upon low density lipoprotein degradation in cultured vascular smooth muscle cells. Cell Biol Int Rep Apr 1985; 9 (4): 323-330.
Bott JH, Evans CL, Darton K, Davies PF. Accurate Dosing of Pregnant and Lactating Rats in Drinking-Water. Teratology Apr 1986; 33 (2): A51-A51.
Dainiak N, Kreczko S, Riordan MA, Warren HB, Davies PF. Lipoproteins Inhibit the Expression of Erythroid Mitogens Present in Media Conditioned by Endothelial-Cells. Experimental Hematology Jul 1986; 14 (6): 428-428.
Dainiak N, Kreczko S, Riordan MA, Warren HB, Davies PF. Lipoproteins Inhibit the Expression of Erythroid Mitogens Present in Media Conditioned by Cultured Endothelial-Cells. Clinical Research Apr 1986; 34 (2): A455-A455.
Davies PF. Vascular cell interactions with special reference to the pathogenesis of atherosclerosis. Lab Invest Jul 1986; 55 (1): 5-24.
Davies PF. Contact-Mediated and Humoral Communication between Vascular Endothelial and Smooth-Muscle Cells-Invitro. Federation Proceedings Mar 1 1986; 45 (3): 685-685.
Davies PF, Gimbrone MA, Gordon EJ, Remuzzi A, Dewey CF. Structural and Functional-Responses of Vascular Endothelial-Cells to Shear-Flow Invitro. Biorheology 1986; 23 (3): 195-195.
Davies PF, Remuzzi A, Gordon EJ, Dewey CF, Jr., Gimbrone MA, Jr. Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proc Natl Acad Sci U S A Apr 1986; 83 (7): 2114-2117.
Einav S, Dewey CF, Davies PF, Gimbrone MA. Time-Varying Turbulent Fluid Characteristics and Vascular Endothelium. Thrombosis Research 1986; 132-132.
Ganz P, Davies PF, Leopold JA, Gimbrone MA, Jr., Alexander RW. Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: effects on cyclic GMP production. Proc Natl Acad Sci U S A May 1986; 83 (10): 3552-3556.
Warren HB, Collins T, Davies PF. C-Sis Rna Expressed by Cholesterol Loaded Bovine Aortic Endothelial-Cells. Federation Proceedings Mar 5 1986; 45 (4): 1073-1073.
Dennis PA, Mendrick DL, Rennke HG, Diehl TS, Davies PF. Intracytoplasmic Delivery of Monoclonal-Antibody V5/1 Directed against 90kd Coated Vesicle Membrane Polypeptide Inhibits Receptor-Mediated Ldl Metabolism in Cultured Vascular Endothelium. Federation Proceedings Mar 1 1987; 46 (3): 975-975.
Ganz P, Berk BC, Leopold JA, Gimbrone MA, Davies PF, Griendling KK, Alexander RW. Novel Endothelium-Derived Activity Inhibiting Hormonal Responsiveness in Vascular Smooth-Muscle. Clinical Research Apr 1987; 35 (3): A571-A571.
Warren HB, Pantazis P, Davies PF. The third component of complement is transcribed and secreted by cultured human endothelial cells. Am J Pathol Oct 1987; 129 (1): 9-13.
Warren HB, Pantazis P, Davies PF. The 3rd Component of Complement Is Transcribed and Secreted by Cultured Human-Endothelial Cells. American Journal of Pathology Oct 1987; 129 (1): 9-13.
Brock TA, Dennis PA, Griendling KK, Diehl TS, Davies PF. GTP gamma S loading of endothelial cells stimulates phospholipase C and uncouples ATP receptors. Am J Physiol Nov 1988; 255 (5 Pt 1): C667-673.
Dainiak N, Warren HB, Kreczko S, Riordan MA, Feldman L, Lawler J, Cohen AM, Davies PF. Acetylated lipoproteins impair erythroid growth factor release from endothelial cells. J Clin Invest Mar 1988; 81 (3): 834-843.
Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. Hypertension Jun 1988; 11 (6 Pt 2): 563-572.
Guinan EC, Smith BR, Davies PF, Pober JS. Cytoplasmic transfer between endothelium and lymphocytes: quantitation by flow cytometry. Am J Pathol Sep 1988; 132 (3): 406-409.
Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature Jan 14 1988; 331 (6152): 168-170.
Olesen SP, Clapham DE, Davies PF. Hemodynamic Shear-Stress Activates a K+ Current in Vascular Endothelial-Cells. Nature Jan 14 1988; 331 (6152): 168-170.
Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. Circ Res Jun 1988; 62 (6): 1059-1064.
Stamler J, Mendelsohn M, Cooke J, Davies PF, Loscalzo J. Inhibition of Platelet-Aggregation by Endothelium-Derived Relaxing Factor Is Potentiated by Reduced Thiols. Clinical Research Apr 1988; 36 (3): A320-A320.
Armstrong MJ, Warren HB, Davies PF, Dainiak N. Nutrition requirements for mammalian cells and hematopoietic growth factor production. Ann N Y Acad Sci 1989; 554 66-74.
Davies PF. How Do Vascular Endothelial-Cells Respond to Flow. News in Physiological Sciences Feb 1989; 4 22-25.
Davies PF, Shevland JE, Townley G. Ante natal diagnosis of extra-lobar sequestration. Australas Radiol Aug 1989; 33 (3): 290-292.
Rybak ME, Gimbrone MA, Jr., Davies PF, Handin RI. Interaction of platelet factor four with cultured vascular endothelial cells. Blood May 1 1989; 73 (6): 1534-1539.
Stamler J, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J. N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res Sep 1989; 65 (3): 789-795.
Cooke JP, Stamler J, Andon N, Davies PF, McKinley G, Loscalzo J. Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol. Am J Physiol Sep 1990; 259 (3 Pt 2): H804-812.
Davies PF, Dull RO. How does the arterial endothelium sense flow? Hemodynamic forces and signal transduction. Adv Exp Med Biol 1990; 273 281-293.
Davies PF. Mechanical sensing mechanisms: shear stress and endothelial cells. J Vasc Surg May 1991; 13 (5): 729-731.
Davies PF, Robotewskyj A, Mckibben S, Griem ML. Measurements of Endothelial-Cell Adhesion in Real-Time Using Confocal Image-Analysis. Faseb Journal Mar 19 1991; 5 (6): A1603-A1603.
Dull RO, Davies PF. Flow modulation of agonist (ATP)-response (Ca2+) coupling in vascular endothelial cells. Am J Physiol Jul 1991; 261 (1 Pt 2): H149-154.
Polacek D, Beckmann MW, Schreiber JR, Davies PF. Correlation of Gap Junction (Gj) Messenger-Rna Levels with Follicular Development in the Rat Ovary by Insitu Hybridization. Faseb Journal Mar 11 1991; 5 (4): A679-A679.
Robotewskyj A, Mckibben S, Dull R, Griem ML, Davies PF. Dynamics of Focal Adhesion Site Remodeling in Living Endothelial-Cells in Response to Shear-Stress Forces Using Confocal Image-Analysis. Faseb Journal Mar 11 1991; 5 (4): A527-A527.
Braddock DT, Davies PF, Meredith SC. A Highly Conserved Anionic Region of Apolipoprotein-E Increases Binding of Ldl to the Ldl Receptor. Circulation Oct 1992; 86 (4): 3-3.
Davies PF, Robotewskyj A, Griem ML, Dull RO, Polacek DC. Hemodynamic forces and vascular cell communication in arteries. Arch Pathol Lab Med Dec 1992; 116 (12): 1301-1306.
DePaola N, Gimbrone MA, Jr., Davies PF, Dewey CF, Jr. Vascular endothelium responds to fluid shear stress gradients. Arterioscler Thromb Nov 1992; 12 (11): 1254-1257.
Dull RO, Tarbell JM, Davies PF. Mechanisms of flow-mediated signal transduction in endothelial cells: kinetics of ATP surface concentrations. J Vasc Res Nov-Dec 1992; 29 (6): 410-419.
Gallimore AP, Davies PF. Meckel syndrome: prenatal ultrasonographic diagnosis in two cases showing marked differences in phenotypic expression. Australas Radiol Feb 1992; 36 (1): 62-64.
Pritchard WF, Davies PF, Polacek DC, Dull RO, Jones SA, Giddens DP. The Pattern of Adhesion of U937 Cells in a Flow Model Is Determined by Local Hemodynamic Factors and Is Modulated by Chemoattractant Gradients. Faseb Journal Feb 26 1992; 6 (4): A1321-A1321.
Bech F, Lan Q, Davies PF, Polacek D. Endothelial Gap Junction Gene-Expression in Hemodynamically-Defined Regions of the Rabbit Aortoiliac Bifurcation. Faseb Journal Feb 23 1993; 7 (4): A638-A638.
Beckmann MW, Polacek D, Wiegratz I, Davies PF, Schreiber JR. Determination of Gap Junction Connexin-43 Messenger-Rna Change during Ovarian Follicular Maturation by Hybridization in-Situ. Archives of Gynecology and Obstetrics Dec 1993; 254 (1-4): 143-145.
Braddock DT, Luo P, Davies PF, Lynn DG, Meredith SC. Conformational-Changes Induced by Cross-Linking Side-Chains Influence Biological-Activity in a Highly Conserved Region of Apolipoprotein-E. Journal of Cellular Biochemistry Feb 8 1993; 214-214.
Davies PF. Endothelium as a signal transduction interface for flow forces: cell surface dynamics. Thromb Haemost Jul 1 1993; 70 (1): 124-128.
Davies PF, Robotewskyj A, Griem ML. Endothelial cell adhesion in real time. Measurements in vitro by tandem scanning confocal image analysis. J Clin Invest Jun 1993; 91 (6): 2640-2652.
Davies PF, Robotewskyj A, Griem ML. Endothelial-Cell Adhesion in Real-Time – Measurements Invitro by Tandem Scanning Confocal Image-Analysis. Journal of Clinical Investigation Jun 1993; 91 (6): 2640-2652.
Davies PF, Shevland JE, Shepherd JJ. Ultrasonography of the pancreas in patients with multiple endocrine neoplasia type I. J Ultrasound Med Feb 1993; 12 (2): 67-72.
Davies PF, Tripathi SC. Mechanical stress mechanisms and the cell. An endothelial paradigm. Circ Res Feb 1993; 72 (2): 239-245.
Depaola N, Gimbrone MA, Davies PF, Dewey CF. Vascular Endothelium Responds to Fluid Shear-Stress Gradients (Vol 12, Pg 1254-1257, 1992). Arteriosclerosis and Thrombosis Mar 1993; 13 (3): 465-465.
Jacobs ER, Cheliakine C, Gebremedhin D, Davies PF, Harder DR. Shear Activated Channels in Cell-Attached Patches of Aortic Endothelial-Cells. Faseb Journal Feb 19 1993; 7 (3): A55-A55.
Polacek D, Bech F, Lan Q, Davies PF. Gap Junction (Gj) Connexin43 (Cx43) Gene-Expression in Early Atherosclerotic Lesions. Faseb Journal Feb 19 1993; 7 (3): A489-A489.
Polacek D, Lal R, Volin MV, Davies PF. Gap junctional communication between vascular cells. Induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions. Am J Pathol Feb 1993; 142 (2): 593-606.
Robotewskyj A, Griem ML, Davies PF. Remodeling of Endothelial Focal Adhesion Sites in Response to Flow – Quantitative Studies by Confocal Image-Analysis. Faseb Journal Feb 19 1993; 7 (3): A54-A54.
Schreiber JR, Beckmann MW, Polacek D, Davies PF. Changes in gap junction connexin-43 messenger ribonucleic acid levels associated with rat ovarian follicular development as demonstrated by in situ hybridization. Am J Obstet Gynecol Apr 1993; 168 (4): 1094-1102; discussion 1102-1094.
Shepherd JJ, Challis DR, Davies PF, McArdle JP, Teh BT, Wilkinson S. Multiple endocrine neoplasm, type 1. Gastrinomas, pancreatic neoplasms, microcarcinoids, the Zollinger-Ellison syndrome, lymph nodes, and hepatic metastases. Arch Surg Oct 1993; 128 (10): 1133-1142.
Barbee KA, Davies PF, Lal R. Shear stress-induced reorganization of the surface topography of living endothelial cells imaged by atomic force microscopy. Circ Res Jan 1994; 74 (1): 163-171.
Barbee KA, Mundel T, Lal R, Davies PF. Distribution of Shear-Stress on the Surface of Aligned and Un-Aligned Endothelial Monolayers. Hypertension Sep 1994; 24 (3): 384-384.
Davies PF, Barbee KA. Endothelial-Cell Surface Imaging – Insights into Hemodynamic Force Transduction. News in Physiological Sciences Aug 1994; 9 153-157.
Davies PF, Robotewskyj A, Griem ML. Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces. J Clin Invest May 1994; 93 (5): 2031-2038.
Lan Q, Mercurius KO, Davies PF. Stimulation of transcription factors NF kappa B and AP1 in endothelial cells subjected to shear stress. Biochem Biophys Res Commun Jun 15 1994; 201 (2): 950-956.
Barbee KA, Mundel T, Lal R, Davies PF. Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers. Am J Physiol Apr 1995; 268 (4 Pt 2): H1765-1772.
Barbee KA, Mundel T, Lal R, Davies PF. Altered Subcellular Shear-Stress Distribution by the Flow-Realignment Response of Endothelial-Cells. Faseb Journal Mar 9 1995; 9 (3): A588-A588.
Baumbach GL, Barbee KA, Brand RA, Griem ML, Davies PF. Effects of Mechanical Deformation on Focal Adhesion Sites in Vascular Smooth-Muscle. Faseb Journal Mar 9 1995; 9 (3): A606-A606.
Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev Jul 1995; 75 (3): 519-560.
Davies PF, Barbee KA, Lal R, Robotewskyj A, Griem ML. Hemodynamics and atherogenesis. Endothelial surface dynamics in flow signal transduction. Ann N Y Acad Sci Jan 17 1995; 748 86-102; discussion 102-103.
Davies PF, Mundel T, Barbee KA. A mechanism for heterogeneous endothelial responses to flow in vivo and in vitro. J Biomech Dec 1995; 28 (12): 1553-1560.
Hijjawi J, Polacek D, Davies PF. Il-1-Alpha Induces the Expression of Gap Junction Connexin-43 in Human Monocyte-Derived Macrophages. Faseb Journal Mar 9 1995; 9 (3): A413-A413.
Jacobs ER, Cheliakine C, Gebremedhin D, Birks EK, Davies PF, Harder DR. Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells. Pflugers Arch Nov 1995; 431 (1): 129-131.
Polacek D, Depaola N, Pritchard W, Davies PF. Spatial up-Regulation of Gap Junction Connexin43 Messenger-Rna in Endothelial-Cells Exposed to Steady Laminar and Disturbed Flows in-Vitro. Faseb Journal Mar 9 1995; 9 (3): A267-A267.
Pritchard WF, Davies PF, Derafshi Z, Polacek DC, Tsao R, Dull RO, Jones SA, Giddens DP. Effects of wall shear stress and fluid recirculation on the localization of circulating monocytes in a three-dimensional flow model. J Biomech Dec 1995; 28 (12): 1459-1469.
Volin MV, Joseph L, Davies PF. Esor1, a 7-Transmembrane G-Protein Coupled Orphan Receptor Cloned from Bovine Aortic Endothelial-Cells. Faseb Journal Mar 10 1995; 9 (4): A871-A871.
Braddock DT, Mercurius KO, Subramanian RM, Dominguez SR, Davies PF, Meredith SC. Conformationally specific enhancement of receptor-mediated LDL binding and internalization by peptide models of a conserved anionic N-terminal domain of human apolipoprotein E. Biochemistry Nov 5 1996; 35 (44): 13975-13984.
Brand RA, Davies PF. Cell biomechanics. J Biomech Apr 1996; 29 (4): 389.
Davies PF. NO flow helps clear murky waters?. Circ Res May 1996; 78 (5): 945-946.
Davies PF, Robotweskyj A, Barbee K, Mundel T, Griem M. Dynamics of endothelial cell tension and adhesion. Journal of Neurochemistry 1996; 66 S100-S100.
Davies PF. Haemodynamic influences on vascular remodelling. Transpl Immunol Dec 1997; 5 (4): 243-245.
Davies PF. Mechanisms involved in endothelial responses to hemodynamic forces. Atherosclerosis Jun 1997; 131 Suppl S15-17.
Davies PF. Overview: temporal and spatial relationships in shear stress-mediated endothelial signalling. J Vasc Res May-Jun 1997; 34 (3): 208-211.
Davies PF. Hemodynamic-related signalling in vascular endothelium. Faseb Journal Jul 31 1997; 11 (9): A1450-A1450.
Davies PF. Temporal and spatial relationships in shear stress-mediated endothelial signalling – Overview. Journal of Vascular Research May-Jun 1997; 34 (3): 208-211.
Davies PF, Barbee KA, Volin MV, Robotewskyj A, Chen J, Joseph L, Griem ML, Wernick MN, Jacobs E, Polacek DC, dePaola N, Barakat AI. Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction. Annu Rev Physiol 1997; 59 527-549.
Polacek D, Bech F, McKinsey JF, Davies PF. Connexin43 gene expression in the rabbit arterial wall: effects of hypercholesterolemia, balloon injury and their combination. J Vasc Res Jan-Feb 1997; 34 (1): 19-30.
Shockley MS, Volin MV, Joseph L, Davies PF. Differential expression of the chemokine receptor CXCR4 in vascular tissue. Molecular Biology of the Cell Nov 1997; 8 1337-1337.
Barakat AI, Davies PF. Mechanisms of shear stress transmission and transduction in endothelial cells. Chest Jul 1998; 114 (1 Suppl): 58S-63S.
DePaola N, Harbeck N, Davies PF, Polacek DC. Sustained impairment of gap junctional communication in vascular endothelial cells exposed to disturbed fluid flow. Molecular Biology of the Cell Nov 1998; 9 123a-123a.
Volin MV, Joseph L, Shockley MS, Davies PF. Chemokine receptor CXCR4 expression in endothelium. Biochem Biophys Res Commun Jan 6 1998; 242 (1): 46-53.
Barakat AI, Leaver EV, Pappone PA, Davies PF. A flow-activated chloride-selective membrane current in vascular endothelial cells. Circ Res Oct 29 1999; 85 (9): 820-828.
Davies PF, Phillips CC, Roberts C. All-optical reflection modulator using a nonlinear heteronipi structure within an asymmetric Fabry-Perot optical cavity. Applied Physics Letters Jun 14 1999; 74 (24): 3717-3719.
Davies PF, Polacek DC, Handen JS, Helmke BP, DePaola N. A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis. Trends Biotechnol Sep 1999; 17 (9): 347-351.
DePaola N, Davies PF, Pritchard WF, Jr., Florez L, Harbeck N, Polacek DC. Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro. Proc Natl Acad Sci U S A Mar 16 1999; 96 (6): 3154-3159.
DePaola N, Harbeck N, Davies PF, Polacek DC. Endothelial gap junctional communication in disturbed flow conditions. Faseb Journal Mar 12 1999; 13 (4): A48-A48.
DePaola N, Polacek DC, Davies PF. Hemodynamic regulation of endothelial communication. American Journal of Hypertension Apr 1999; 12 (4): 211a-211a.
Ganepola SA, Shockley MS, Davies PF. Influence of extracellular matrix components on CXCR4 expression in vascular endothelium.. Faseb Journal Mar 12 1999; 13 (4): A463-A463.
Gimbrone MA, Jr., Anderson KR, Topper JN, Langille BL, Clowes AW, Bercel S, Davies MG, Stenmark KR, Frid MG, Weiser-Evans MC, Aldashev AA, Nemenoff RA, Majesky MW, Landerholm TE, Lu J, Ito WD, Arras M, Scholz D, Imhof B, Aurrand-Lions M, Schaper W, Nagel TE, Resnick N, Dewey CF, Gimbrone MA, Davies PF. Special communicationthe critical role of mechanical forces in blood vessel development, physiology and pathology. J Vasc Surg Jun 1999; 29 (6): 1104-1151.
Handen JS, Polacek D, DePaola N, Davies PF. Single cell and regional endothelial gene expression in In Vitro models of flow. Faseb Journal Mar 15 1999; 13 (5): A857-A857.
Helmke BP, Goldman RD, Davies PF. Rapid displacement of vimentin intermediate filaments in living endothelial cells. Molecular Biology of the Cell Nov 1999; 10 11a-11a.
Helmke BP, Goldman RD, Davies PF. Cytoskeletal dynamics in living endothelial cells exposed to steady laminar shear stress. Faseb Journal Mar 15 1999; 13 (5): A1019-A1019.
Helmke BP, Handen JS, Davies PF. Dynamics of the actin cytoskeleton in living endothelial cells. Faseb Journal Mar 15 1999; 13 (5): A714-A714.
Seetharam A, Helmke BP, Goldman RD, Davies PF. Intermediate filament dynamics in bovine aortic endothelial cells are altered dy shear stress. Faseb Journal Mar 15 1999; 13 (5): A855-A855.
Shockley MS, Volin M, Joseph L, Davies PF. The chemokine receptor CXCR4 is expressed in atherosclerotic lesions.. Faseb Journal Mar 15 1999; 13 (5): A692-A692.
Davies PF. Spatial hemodynamics, the endothelium, and focal atherogenesis: a cell cycle link?. Circ Res Feb 4 2000; 86 (2): 114-116.
Helmke BP, Goldman RD, Davies PF. Rapid displacement of vimentin intermediate filaments in living endothelial cells exposed to flow. Circ Res Apr 14 2000; 86 (7): 745-752.
Helmke BP, Goldman RD, Davies PF. Rapid displacement of intermediate filaments in endothelial cells exposed to shear stress. Faseb Journal Mar 15 2000; 14 (4): A449-A449.
Levitan I, Helmke BP, Davies PF. A chamber to permit invasive manipulation of adherent cells in laminar flow with minimal disturbance of the flow field. Ann Biomed Eng 2000; 28 (10): 1184-1193.
Rizzo V, DePaola N, Schnitzer JE, Davies PF. Caveolae expression regulates endothelial cell surface mechano-responsiveness.. Faseb Journal Mar 15 2000; 14 (4): A457-A457.
Davies PF, Shi C, Depaola N, Helmke BP, Polacek DC. Hemodynamics and the focal origin of atherosclerosis: a spatial approach to endothelial structure, gene expression, and function. Ann N Y Acad Sci Dec 2001; 947 7-16; discussion 16-17.
Hardy P, McNamara P, Lakins JN, Davies PF. Arterial shear stress increases peroxisome proliferator-activated receptor gamma expression in human aortic endothelial cells.. Arteriosclerosis Thrombosis and Vascular Biology Apr 2001; 21 (4): 684-684.
Helmke BP, Rosen AB, Davies PF. Measurement of cytoskeletal strain field induced by shear stress in living endothelial cells. Arteriosclerosis Thrombosis and Vascular Biology Apr 2001; 21 (4): 715-715.
Helmke BP, Thakker DB, Goldman RD, Davies PF. Spatiotemporal analysis of flow-induced intermediate filament displacement in living endothelial cells. Biophys J Jan 2001; 80 (1): 184-194.
Davies PF. Multiple signaling pathways in flow-mediated endothelial mechanotransduction: PYK-ing the right location. Arterioscler Thromb Vasc Biol Nov 1 2002; 22 (11): 1755-1757.
Davies PF, Polacek DC, Shi C, Helmke BP. The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosis. Biorheology 2002; 39 (3-4): 299-306.
Helmke BP, Davies PF. The cytoskeleton under external fluid mechanical forces: hemodynamic forces acting on the endothelium. Ann Biomed Eng Mar 2002; 30 (3): 284-296.
Romanenko VG, Davies PF, Levitan I. Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cells. Am J Physiol Cell Physiol Apr 2002; 282 (4): C708-718.
Zhang JC, Helmke BP, Shum A, Du K, Yu WW, Lu MM, Davies PF, Parmacek MS. SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expression. Mech Dev Jul 2002; 115 (1-2): 161-166.
Davies PF, Zilberberg J, Helmke BP. Spatial microstimuli in endothelial mechanosignaling. Circ Res Mar 7 2003; 92 (4): 359-370.
Helmke BP, Rosen AB, Davies PF. Mapping mechanical strain of an endogenous cytoskeletal network in living endothelial cells. Biophys J Apr 2003; 84 (4): 2691-2699.
Passerini AG, Polacek DC, Shi CZ, Davies PF. Fidelity and enhanced sensitivity of differential transcription profiles following linear amplification of nanogram amounts of endothelial mRNA. Faseb Journal Mar 14 2003; 17 (4): A273-A274.
Polacek DC, Passerini AG, Shi C, Francesco NM, Manduchi E, Grant GR, Powell S, Bischof H, Winkler H, Stoeckert CJ, Jr., Davies PF. Fidelity and enhanced sensitivity of differential transcription profiles following linear amplification of nanogram amounts of endothelial mRNA. Physiol Genomics Apr 16 2003; 13 (2): 147-156.
Rizzo V, Morton C, DePaola N, Schnitzer JE, Davies PF. Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro. Am J Physiol Heart Circ Physiol Oct 2003; 285 (4): H1720-1729.
Zilberberg J, Davies PF. Modeling of shear stress distribution following monocyte adhesion to endothelial cell monolayers. Faseb Journal Mar 17 2003; 17 (5): A1355-A1355.
Davies PF. Molecular phenotypes of atherosclerosis: fingering the perpetrators. Arterioscler Thromb Vasc Biol Oct 2004; 24 (10): 1746-1747.
Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arterioscler Thromb Vasc Biol Aug 2004; 24 (8): 1331-1333.
Fang Y, Romanenko V, Shi CZ, Schram G, Nattel S, Davies PF, Levitan I. Molecular and functional characterization of inwardly rectifier potassium current in human aortic endothelial cells (HAECs). Biophysical Journal Jan 2004; 86 (1): 442a-442a.
Kaufman DA, Albelda SM, Sun J, Davies PF. Role of lateral cell-cell border location and extracellular/transmembrane domains in PECAM/CD31 mechanosensation. Biochem Biophys Res Commun Aug 6 2004; 320 (4): 1076-1081.
Mackie GC, Davies PF, Challis DR, Middleton IS. Renal infarction secondary to a subcapsular haematoma following percutaneous renal biopsy. Australas Radiol Jun 2004; 48 (2): 207-210.
Passerini AG, Polacek DC, Shi C, Francesco NM, Manduchi E, Grant GR, Pritchard WF, Powell S, Chang GY, Stoeckert CJ, Jr., Davies PF. Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc Natl Acad Sci U S A Feb 24 2004; 101 (8): 2482-2487.
Simmons CA, Zilberberg J, Davies PF. A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Ann Biomed Eng Oct 2004; 32 (10): 1453-1459.
Davies PF. Hemodynamic manipulation of eNOS in vivo. Blood Dec 1 2005; 106 (12): 3679-3680.
Davies PF, Spaan JA, Krams R. Shear stress biology of the endothelium. Ann Biomed Eng Dec 2005; 33 (12): 1714-1718.
Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am J Physiol Cell Physiol Nov 2005; 289 (5): C1134-1144.
Magid R, Davies PF. Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aorta. Circ Res Sep 2 2005; 97 (5): 443-449.
Passerini AG, Shi C, Francesco NM, Chuan P, Manduchi E, Grant GR, Stoeckert CJ, Jr., Karanian JW, Wray-Cahen D, Pritchard WF, Davies PF. Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet. Biochem Biophys Res Commun Jun 24 2005; 332 (1): 142-148.
Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circ Res Apr 15 2005; 96 (7): 792-799.
Davies PF, Litt M. Interdisciplinary BME education: a clinical preceptorship course for undergraduate bioengineering students. Ann Biomed Eng Feb 2006; 34 (2): 276-281.
DeLisser HM, Helmke BP, Cao G, Egan PM, Taichman D, Fehrenbach M, Zaman A, Cui Z, Mohan GS, Baldwin HS, Davies PF, Savani RC. Loss of PECAM-1 function impairs alveolarization. J Biol Chem Mar 31 2006; 281 (13): 8724-8731.
DeLisser HM, Helmke BP, Cao GY, Egan PM, Taichman D, Fehrenbach M, Zaman A, Cui Z, Mohan GS, Baldwin HS, Davies PF, Savani RC. Loss of PECAM-1 function impairs alveolarization. Journal of Biological Chemistry Mar 31 2006; 281 (13): 8724-8731.
Fang Y, Mohler ER, 3rd, Hsieh E, Osman H, Hashemi SM, Davies PF, Rothblat GH, Wilensky RL, Levitan I. Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo. Circ Res Apr 28 2006; 98 (8): 1064-1071.
Davies PF. Endothelial mechanisms of flow-mediated athero-protection and susceptibility. Circ Res Jul 6 2007; 101 (1): 10-12.
Davies PF, Shi CZ, Manduchi E, Passerini AG. Endothelial phenotype profiles identified in vivo by convergence of differential mRNA and microRNA expression at flow-sensitive athero-susceptible sites in normal swine aortas. Faseb Journal Apr 2007; 21 (5): A186-A186.
Helmke BP, Davies PF. Chambers for Examination of Live Cells under Mechanical Stress. CSH Protoc 2007; 2007 pdb ip32.
Karamanian AA, Davies PF. Low expression of endothelial Claudin-5 correlates with sites vulnerable to atherosclerosis. Faseb Journal Apr 2007; 21 (6): A752-A752.
Raj JU, Aliferis C, Caprioli RM, Cowley AW, Jr., Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol Jul 2007; 293 (1): L45-51.
Civelek M, Grant GR, Irolla CR, Stoeckert CJ, Karanian JW, Chiesa OA, Pritchard WF, Davies PF. ABCA1 is upregulated in athero-protected regions of arteries in response to brief hypercholesterolemia treatment in vivo. Faseb Journal Apr 2008; 22
Civelek M, Manduchi E, Riley R, Grant GR, Stoeckert CJ, Davies PF. Coronary artery endothelial phenotype differences related to atherosusceptibility emerge from a multi-arterial site analysis in adult swine. Faseb Journal Apr 2008; 22
Davies PF. Endothelial transcriptome profiles in vivo in complex arterial flow fields. Ann Biomed Eng Apr 2008; 36 (4): 563-570.
Davies PF. Endothelial phenotype plasticity in patho-susceptible unstable flow regions of the cardiovascular system. European Journal of Clinical Investigation Apr 2008; 38 24-24.
Fang Y, Davies PF. Site-specific differential expression of endothelial KLF4 in athero-susceptible and athero-protective regions of porcine aorta. Faseb Journal Apr 2008; 22
Guerraty MA, Grant GR, Karanian JW, Chiesa OA, Pritchard WF, Davies PF. Brief hypercholesterolemia induces athero-protective pathways on the patho-susceptible aortic side endothelium of swine aortic valves. Faseb Journal Apr 2008; 22
Karamanian AA, Davies PF. Low Expression of Claudin-5, a flow-sensitive endothelial tight junction molecule, correlates with sites vulnerable to atherosclerosis in vivo. Faseb Journal Apr 2008; 22
Shi CZ, Fang Y, Karamanian A, Manduchi E, Davies PF. MicroRNA 10a/10b regulation of endothelial phenotype in atherosusceptible and protected sites in adult swine aorta. Faseb Journal Apr 2008; 22
Trojanowski JQ, Hendricks JC, Jedrziewski K, Johnson FB, Michel KE, Hess RS, Cancro MP, Sleeper MM, Pignolo R, Teff KL, Aguirre GD, Lee VM, Lawler DF, Pack AI, Davies PF. Exploring human/animal intersections: converging lines of evidence in comparative models of aging. Alzheimers Dement Jan 2008; 4 (1): 1-5.
Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Jr., Davies PF. Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis. Circ Res Aug 28 2009; 105 (5): 453-461.
Davies PF. Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology. Nat Clin Pract Cardiovasc Med Jan 2009; 6 (1): 16-26.
Jimenez JM, Davies PF. Hemodynamically driven stent strut design. Ann Biomed Eng Aug 2009; 37 (8): 1483-1494.
Civelek M, Grant GR, Irolla CR, Shi C, Riley RJ, Chiesa OA, Stoeckert CJ, Jr., Karanian JW, Pritchard WF, Davies PF. Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo. Am J Physiol Heart Circ Physiol Jan 2010; 298 (1): H163-170.
Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG. Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo. Semin Thromb Hemost Apr 2010; 36 (3): 265-275.
Fang Y, Shi C, Manduchi E, Civelek M, Davies PF. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A Jul 27 2010; 107 (30): 13450-13455.
Guerraty MA, Grant GR, Karanian JW, Chiesa OA, Pritchard WF, Davies PF. Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium. Arterioscler Thromb Vasc Biol Feb 2010; 30 (2): 225-231.
Civelek M, Manduchi E, Grant GR, Stoeckert CJ, Jr., Davies PF. Discovery approaches to UPR in athero-susceptible endothelium in vivo. Methods Enzymol 2011; 489 109-126.
Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Jr., Davies PF. Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis. Circ Cardiovasc Genet Jun 2011; 4 (3): 243-252.
Davies PF, Civelek M. Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress. Antioxid Redox Signal Sep 1 2011; 15 (5): 1427-1432.
Davies PF, Guerraty MA. Getting physical with the aortic valve. Arterioscler Thromb Vasc Biol Mar 2011; 31 (3): 474-475.
Guerraty MA, Grant GR, Karanian JW, Chiesa OA, Pritchard WF, Davies PF. Side-specific expression of activated leukocyte adhesion molecule (ALCAM; CD166) in pathosusceptible regions of swine aortic valve endothelium. J Heart Valve Dis Mar 2011; 20 (2): 165-167.
Waters SL, Alastruey J, Beard DA, Bovendeerd PH, Davies PF, Jayaraman G, Jensen OE, Lee J, Parker KH, Popel AS, Secomb TW, Siebes M, Sherwin SJ, Shipley RJ, Smith NP, van de Vosse FN. Theoretical models for coronary vascular biomechanics: progress & challenges. Prog Biophys Mol Biol Jan 2011; 104 (1-3): 49-76.
Fang Y, Davies PF. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol Apr 2012; 32 (4): 979-987.
Han J, Zern BJ, Shuvaev VV, Davies PF, Muro S, Muzykantov V. Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1. ACS Nano Oct 23 2012; 6 (10): 8824-8836.
Davies PF, Civelek M, Fang Y, Fleming I. The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo. Cardiovasc Res Jul 15 2013; 99 (2): 315-327.
Jimenez JM, Prasad V, Yu MD, Kampmeyer CP, Kaakour AH, Wang PJ, Maloney SF, Wright N, Johnston I, Jiang YZ, Davies PF. Macro- and microscale variables regulate stent haemodynamics, fibrin deposition and thrombomodulin expression. J R Soc Interface 2014; 11 (94): 20131079.