Professor of Pathology and Laboratory Medicine
Cell and Molecular Biology
University of Pennsylvania
Perelman School of Medicine
240 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6055
Office: (215) 898-2874
Fax: (215) 573-7945
Glen N. Gaulton, Ph.D. is Executive Vice Dean, Chief Scientific Officer, and Professor of Pathology and Laboratory of Medicine at the The Perelman School of Medicine at the University of Pennsylvania. As Executive Vice Dean and Chief Scientific Officer, Dr. Gaulton has operational, planning, and financial responsibility for the academic component of all research endeavors and research training missions within the School of Medicine. This includes the Offices of Research Program Development, Combined Degree and Physician Scholar Programs, Biomedical Graduate Studies, Postdoctoral Programs, Masters Programs, Corporate Alliances, Global Health, and Human Research.
Dr. Gaulton received the Ph.D. in biochemistry and molecular biology from the University of California, Santa Barbara. He conducted postgraduate research in immunology at the School of Public Health and School of Medicine at Harvard University. Dr. Gaulton was appointed Assistant Professor of Pathology and Laboratory Medicine in the School of Medicine at the University of Pennsylvania in 1987, as Associate Professor with tenure in 1991, and as a full Professor in 1998. Dr. Gaulton was appointed Associate Dean and Director of the Combined Degree and Physician Scholar Programs in 1993, Director of Biomedical Graduate Studies in 1995, Vice Dean for Research and Research Training in 1998 and Executive Vice Dean and Chief Scientific Officer in 2006.
Dr. Gaulton’s research interests are in the areas of lymphocyte growth and viral pathogenesis. This work centers on a molecular description of the mechanisms that control lymphocyte development, the induction of immunological non responsiveness, and the perturbation of these processes by human and murine retroviruses. Dr. Gaulton has published over 100 manuscripts and texts, and directly supervised the research training of over twenty graduate students and fellows. Dr. Gaulton serves on the editorial review panel of nine journals and has been chair of three NIH study sections. He has received numerous awards for teaching and research, including the Deans Award for Basic Science Teaching, the Berwick Memorial Teaching Award, the Linback Award, the Harry Weaver Neuroscience Scholar Award from the National Multiple Sclerosis Society, and the Leukemia Society Scholar Award.
Lymphocyte development and retroviral pathology.
The interests of the Gaulton laboratory focus on an increased understanding of the molecular processes that regulate the infection and pathology of retroviruses, such as HIV, the impact of these infections on the immune system, and the detection of these infections using novel imaging and diagnostic approaches. More specifically, the laboratory has investigated the effects of human and, as experimental models, murine retroviruses during active infection of adult, pediatric and neonatal subjects. Recent results have identified the primary mechanisms whereby retroviruses induce cell destruction through cell-cell fusion, also know as syncytia formation. The laboratory has pioneered the use of magnetic resonance imaging (MRI) techniques to detect HIV infection within cells and is now applying these techniques to in vivo, whole body imaging of active infections. Lastly, using state-of-the-art engineering technology, the laboratory is developing highly sensitive yet mobile, hand-held devices to detect HIV infection in blood. These devices are critical for diagnosing new infections, and to monitor HIV levels in patients undergoing active therapy and/or participating in vaccine trials.