Paul A. Janmey, Ph.D.

Paul Janmey, Ph.D.

Paul Janmey, Ph.D.

Professor
IME & Department of Physiology
1010 Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104-6393
(215) 573-7380, phone
(215) 573-7227, fax
Email: janmey@mail.med.upenn.edu

Education

Research Fellow (1982-1984) Hematology-Oncology Unit, Massachusetts General Hospital

Research Fellow (1982) Department of Chemistry, University of Wisconsin

Ph.D. (1982) Physical Chemistry, University of Wisconsin

A.B. (1976) Chemistry and Philosophy, Oberlin College

Honors and Awards

Rotschild-Yvette Mayent Award, Institut Curie, 1999

Research

Paul’s lab studies how forces applied to the cell or the stiffness of the extracellular matrix affects cell structure and function. He an his group produce soft biocompatible materials to study how matrix stiffness alters cell structure, differentiation, and growth. In related work, Paul’s lab measures the structure and mechanics of cytoskeletal and extracellular matrix polymers using imaging, scattering, and rheologic methods, and examines how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.

Our lab studies several aspects of cell mechanics. In one project, we produce soft materials, usually hydrogels, to which cell adhesion proteins are linked to study how the stiffness of surfaces alters cell structure, function, and growth. Endothelial cells, fibroblasts, neurons and astrocytes each show unique dependence on substrate stiffness, and we seek to understand how they sense and respond to this mechanical cue. In related work we measure the structure and mechanics of cytoskeletal polymers using a variety of imaging, scattering, and rheologic methods. Further studies examine how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.

Bibliography

Bale MD, Janmey PA, Ferry JD. Kinetics of formation of fibrin oligomers. II. Size distributions of ligated oligomers. Biopolymers Nov 1982; 21 (11): 2265-2277.

Janmey PA. Kinetics of formation of fibrin oligomers. I. Theory. Biopolymers Nov 1982; 21 (11): 2253-2264.

Williams EC, Janmey PA, Ferry JD, Mosher DF. Conformational states of fibronectin. Effects of pH, ionic strength, and collagen binding. J Biol Chem Dec 25 1982; 257 (24): 14973-14978.

Janmey PA, Bale MD, Ferry JD. Polymerization of fibrin: analysis of light-scattering data and relation to a peptide release. Biopolymers Sep 1983; 22 (9): 2017-2019.

Janmey PA, Erdile L, Bale MD, Ferry JD. Kinetics of fibrin oligomer formation observed by electron microscopy. Biochemistry Aug 30 1983; 22 (18): 4336-4340.

Williams EC, Janmey PA, Johnson RB, Mosher DF. Fibronectin. Effect of disulfide bond reduction on its physical and functional properties. J Biol Chem May 10 1983; 258 (9): 5911-5914.

Bale MD, Janmey PA, Ferry JD, Lorand L. Kinetics of formation of fibrin oligomers. III. Ligation kinetics concurrent with and subsequent to oligomer assembly. Biopolymers Jan 1984; 23 (1): 127-138.

Lind SE, Janmey PA. Human plasma gelsolin binds to fibronectin. J Biol Chem Nov 10 1984; 259 (21): 13262-13266.

Janmey PA, Chaponnier C, Lind SE, Zaner KS, Stossel TP, Yin HL. Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking. Biochemistry Jul 2 1985; 24 (14): 3714-3723.

Janmey PA, Lind SE, Yin HL, Stossel TP. Effects of semi-dilute actin solutions on the mobility of fibrin protofibrils during clot formation. Biochim Biophys Acta Aug 16 1985; 841 (2): 151-158.

Kwiatkowski DJ, Janmey PA, Mole JE, Yin HL. Isolation and properties of two actin-binding domains in gelsolin. J Biol Chem Dec 5 1985; 260 (28): 15232-15238.

Stossel TP, Chaponnier C, Ezzell RM, Hartwig JH, Janmey PA, Kwiatkowski DJ, Lind SE, Smith DB, Southwick FS, Yin HL, et al. Nonmuscle actin-binding proteins. Annu Rev Cell Biol 1985; 1 353-402.

Chaponnier C, Janmey PA, Yin HL. The actin filament-severing domain of plasma gelsolin. J Cell Biol Oct 1986; 103 (4): 1473-1481.

Janmey PA, Ferry JD. Gel formation by fibrin oligomers without addition of monomers. Biopolymers Jul 1986; 25 (7): 1337-1344.

Janmey PA, Peetermans J, Zaner KS, Stossel TP, Tanaka T. Structure and mobility of actin filaments as measured by quasielastic light scattering, viscometry, and electron microscopy. J Biol Chem Jun 25 1986; 261 (18): 8357-8362.

Janmey PA, Stossel TP. Kinetics of actin monomer exchange at the slow growing ends of actin filaments and their relation to the elongation of filaments shortened by gelsolin. J Muscle Res Cell Motil Oct 1986; 7 (5): 446-454.

Janmey PA, Stossel TP, Lind SE. Sequential binding of actin monomers to plasma gelsolin and its inhibition by vitamin D-binding protein. Biochem Biophys Res Commun Apr 14 1986; 136 (1): 72-79.

Lind SE, Smith DB, Janmey PA, Stossel TP. Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation. J Clin Invest Sep 1986; 78 (3): 736-742.

Janmey PA, Iida K, Yin HL, Stossel TP. Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin. J Biol Chem Sep 5 1987; 262 (25): 12228-12236.

Janmey PA, Lind SE. Capacity of human serum to depolymerize actin filaments. Blood Aug 1987; 70 (2): 524-530.

Janmey PA, Stossel TP. Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature Jan 22-28 1987; 325 (6102): 362-364.

Lind SE, Janmey PA, Chaponnier C, Herbert TJ, Stossel TP. Reversible binding of actin to gelsolin and profilin in human platelet extracts. J Cell Biol Aug 1987; 105 (2): 833-842.

Smith DB, Janmey PA, Herbert TJ, Lind SE. Quantitative measurement of plasma gelsolin and its incorporation into fibrin clots. J Lab Clin Med Aug 1987; 110 (2): 189-195.

Hartwig JH, Zaner KS, Janmey PA. The cortical actin gel of macrophages. Soc Gen Physiol Ser 1988; 43 125-140.

Janmey PA, Hvidt S, Peetermans J, Lamb J, Ferry JD, Stossel TP. Viscoelasticity of F-actin and F-actin/gelsolin complexes. Biochemistry Oct 18 1988; 27 (21): 8218-8227.

Janmey PA, Matsudaira PT. Functional comparison of villin and gelsolin. Effects of Ca2+, KCl, and polyphosphoinositides. J Biol Chem Nov 15 1988; 263 (32): 16738-16743.

Lind SE, Smith DB, Janmey PA, Stossel TP. Depression of gelsolin levels and detection of gelsolin-actin complexes in plasma of patients with acute lung injury. Am Rev Respir Dis Aug 1988; 138 (2): 429-434.

Matsudaira P, Janmey P. Pieces in the actin-severing protein puzzle. Cell Jul 15 1988; 54 (2): 139-140.

Smith DB, Janmey PA, Lind SE. Circulating actin-gelsolin complexes following oleic acid-induced lung injury. Am J Pathol Feb 1988; 130 (2): 261-267.

Smith DB, Janmey PA, Sherwood JA, Howard RJ, Lind SE. Decreased plasma gelsolin levels in patients with Plasmodium falciparum malaria: a consequence of hemolysis?. Blood Jul 1988; 72 (1): 214-218.

Yin HL, Iida K, Janmey PA. Identification of a polyphosphoinositide-modulated domain in gelsolin which binds to the sides of actin filaments. J Cell Biol Mar 1988; 106 (3): 805-812.

Hartwig JH, Janmey PA. Stimulation of a calcium-dependent actin nucleation activity by phorbol 12-myristate 13-acetate in rabbit macrophage cytoskeletons. Biochim Biophys Acta Jan 17 1989; 1010 (1): 64-71.

Janmey PA, Stossel TP. Gelsolin-polyphosphoinositide interaction. Full expression of gelsolin-inhibiting function by polyphosphoinositides in vesicular form and inactivation by dilution, aggregation, or masking of the inositol head group. J Biol Chem Mar 25 1989; 264 (9): 4825-4831.

Kwiatkowski DJ, Janmey PA, Yin HL. Identification of critical functional and regulatory domains in gelsolin. J Cell Biol May 1989; 108 (5): 1717-1726.

Janmey PA, Hvidt S, Lamb J, Stossel TP. Resemblance of actin-binding protein/actin gels to covalently crosslinked networks. Nature May 3 1990; 345 (6270): 89-92.

Janmey PA, Hvidt S, Oster GF, Lamb J, Stossel TP, Hartwig JH. Effect of ATP on actin filament stiffness. Nature Sep 6 1990; 347 (6288): 95-99.

Yin HL, Janmey PA, Schleicher M. Severin is a gelsolin prototype. FEBS Lett May 7 1990; 264 (1): 78-80.

Bresnick AR, Janmey PA, Condeelis J. Evidence that a 27-residue sequence is the actin-binding site of ABP-120. J Biol Chem Jul 15 1991; 266 (20): 12989-12993.

Goldschmidt-Clermont PJ, Janmey PA. Profilin, a weak CAP for actin and RAS. Cell Aug 9 1991; 66 (3): 419-421.

Janmey PA. Mechanical properties of cytoskeletal polymers. Curr Opin Cell Biol Feb 1991; 3 (1): 4-11.

Janmey PA. Polyproline affinity method for purification of platelet profilin and modification with pyrene-maleimide. Methods Enzymol 1991; 196 92-99.

Janmey PA. A torsion pendulum for measurement of the viscoelasticity of biopolymers and its application to actin networks. J Biochem Biophys Methods Jan 1991; 22 (1): 41-53.

Janmey PA, Euteneuer U, Traub P, Schliwa M. Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. J Cell Biol Apr 1991; 113 (1): 155-160.

Burlacu S, Janmey PA, Borejdo J. Distribution of actin filament lengths measured by fluorescence microscopy. Am J Physiol Mar 1992; 262 (3 Pt 1): C569-577.

Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers HR, Stossel TP. Actin-binding protein requirement for cortical stability and efficient locomotion. Science Jan 17 1992; 255 (5042): 325-327.

Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature Apr 16 1992; 356 (6370): 618-622.

Janmey PA, Lamb J, Allen PG, Matsudaira PT. Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin. J Biol Chem Jun 15 1992; 267 (17): 11818-11823.

Janmey PA, Lamb JA, Ezzell RM, Hvidt S, Lind SE. Effects of actin filaments on fibrin clot structure and lysis. Blood Aug 15 1992; 80 (4): 928-936.

Jongstra-Bilen J, Janmey PA, Hartwig JH, Galea S, Jongstra J. The lymphocyte-specific protein LSP1 binds to F-actin and to the cytoskeleton through its COOH-terminal basic domain. J Cell Biol Sep 1992; 118 (6): 1443-1453.

Katakami Y, Katakami N, Janmey PA, Hartwig JH, Stossel TP. Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex. Biochim Biophys Acta Jul 31 1992; 1122 (2): 123-135.

Yu FX, Sun HQ, Janmey PA, Yin HL. Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin. J Biol Chem Jul 25 1992; 267 (21): 14616-14621.

Janmey P. Cell biology. A slice of the actin. Nature Aug 19 1993; 364 (6439): 675-676.

Laham LE, Lamb JA, Allen PG, Janmey PA. Selective binding of gelsolin to actin monomers containing ADP. J Biol Chem Jul 5 1993; 268 (19): 14202-14207.

Lamb JA, Allen PG, Tuan BY, Janmey PA. Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement. J Biol Chem Apr 25 1993; 268 (12): 8999-9004.

Moon AL, Janmey PA, Louie KA, Drubin DG. Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol Jan 1993; 120 (2): 421-435.

Allen PG, Janmey PA. Gelsolin displaces phalloidin from actin filaments. A new fluorescence method shows that both Ca2+ and Mg2+ affect the rate at which gelsolin severs F-actin. J Biol Chem Dec 30 1994; 269 (52): 32916-32923.

Janmey PA. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly. Annu Rev Physiol 1994; 56 169-191.

Janmey PA, Hvidt S, Kas J, Lerche D, Maggs A, Sackmann E, Schliwa M, Stossel TP. The mechanical properties of actin gels. Elastic modulus and filament motions. J Biol Chem Dec 23 1994; 269 (51): 32503-32513.

Lo SH, An Q, Bao S, Wong WK, Liu Y, Janmey PA, Hartwig JH, Chen LB. Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization. J Biol Chem Sep 2 1994; 269 (35): 22310-22319.

Lo SH, Janmey PA, Hartwig JH, Chen LB. Interactions of tensin with actin and identification of its three distinct actin-binding domains. J Cell Biol Jun 1994; 125 (5): 1067-1075.

Sun HQ, Wooten DC, Janmey PA, Yin HL. The actin side-binding domain of gelsolin also caps actin filaments. Implications for actin filament severing. J Biol Chem Apr 1 1994; 269 (13): 9473-9479.

Takata S, Matsubara M, Allen PG, Janmey PA, Serhan CN, Brady HR. Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium. J Clin Invest Feb 1994; 93 (2): 499-508.

Van Etten RA, Jackson PK, Baltimore D, Sanders MC, Matsudaira PT, Janmey PA. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity. J Cell Biol Feb 1994; 124 (3): 325-340.

Vasconcellos CA, Allen PG, Wohl ME, Drazen JM, Janmey PA, Stossel TP. Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science Feb 18 1994; 263 (5149): 969-971.

Chaponnier C, Goethals M, Janmey PA, Gabbiani F, Gabbiani G, Vandekerckhove J. The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo. J Cell Biol Aug 1995; 130 (4): 887-895.

Fujita H, Laham LE, Janmey PA, Kwiatkowski DJ, Stossel TP, Banno Y, Nozawa Y, Mullauer L, Ishizaki A, Kuzumaki N. Functions of [His321]gelsolin isolated from a flat revertant of ras-transformed cells. Eur J Biochem May 1 1995; 229 (3): 615-620.

Gieselmann R, Kwiatkowski DJ, Janmey PA, Witke W. Distinct biochemical characteristics of the two human profilin isoforms. Eur J Biochem May 1 1995; 229 (3): 621-628.

Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell Aug 25 1995; 82 (4): 643-653.

Janmey PA. Protein regulation by phosphatidylinositol lipids. Chem Biol Feb 1995; 2 (2): 61-65.

Janmey PA, Chaponnier C. Medical aspects of the actin cytoskeleton. Curr Opin Cell Biol Feb 1995; 7 (1): 111-117.

Laham LE, Way M, Yin HL, Janmey PA. Identification of two sites in gelsolin with different sensitivities to adenine nucleotides. Eur J Biochem Nov 15 1995; 234 (1): 1-7.

MacKintosh FC, Kas J, Janmey PA. Elasticity of semiflexible biopolymer networks. Phys Rev Lett Dec 11 1995; 75 (24): 4425-4428.

Vegners R, Shestakova I, Kalvinsh I, Ezzell RM, Janmey PA. Use of a gel-forming dipeptide derivative as a carrier for antigen presentation. J Pept Sci Nov-Dec 1995; 1 (6): 371-378.

Xian W, Vegners R, Janmey PA, Braunlin WH. Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles. Biophys J Dec 1995; 69 (6): 2695-2702.

Allen PG, Laham LE, Way M, Janmey PA. Binding of phosphate, aluminum fluoride, or beryllium fluoride to F-actin inhibits severing by gelsolin. J Biol Chem Mar 1 1996; 271 (9): 4665-4670.

Allen PG, Shuster CB, Kas J, Chaponnier C, Janmey PA, Herman IM. Phalloidin binding and rheological differences among actin isoforms. Biochemistry Nov 12 1996; 35 (45): 14062-14069.

Bao L, Loda M, Janmey PA, Stewart R, Anand-Apte B, Zetter BR. Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer. Nat Med Dec 1996; 2 (12): 1322-1328.

Eichinger L, Koppel B, Noegel AA, Schleicher M, Schliwa M, Weijer K, Witke W, Janmey PA. Mechanical perturbation elicits a phenotypic difference between Dictyostelium wild-type cells and cytoskeletal mutants. Biophys J Feb 1996; 70 (2): 1054-1060.

Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem Dec 20 1996; 271 (51): 32986-32993.

Janmey PA. Coping with cellular stress: the mechanical resistance of porous protein networks. Biophys J Jul 1996; 71 (1): 3-5.

Janssen KP, Eichinger L, Janmey PA, Noegel AA, Schliwa M, Witke W, Schleicher M. Viscoelastic properties of F-actin solutions in the presence of normal and mutated actin-binding proteins. Arch Biochem Biophys Jan 15 1996; 325 (2): 183-189.

Kas J, Strey H, Tang JX, Finger D, Ezzell R, Sackmann E, Janmey PA. F-actin, a model polymer for semiflexible chains in dilute, semidilute, and liquid crystalline solutions. Biophys J Feb 1996; 70 (2): 609-625.

Leterrier JF, Kas J, Hartwig J, Vegners R, Janmey PA. Mechanical effects of neurofilament cross-bridges. Modulation by phosphorylation, lipids, and interactions with F-actin. J Biol Chem Jun 28 1996; 271 (26): 15687-15694.

Prochniewicz E, Zhang Q, Janmey PA, Thomas DD. Cooperativity in F-actin: binding of gelsolin at the barbed end affects structure and dynamics of the whole filament. J Mol Biol Aug 2 1996; 260 (5): 756-766.

Sheils CA, Kas J, Travassos W, Allen PG, Janmey PA, Wohl ME, Stossel TP. Actin filaments mediate DNA fiber formation in chronic inflammatory airway disease. Am J Pathol Mar 1996; 148 (3): 919-927.

Tang JX, Janmey PA. The polyelectrolyte nature of F-actin and the mechanism of actin bundle formation. J Biol Chem Apr 12 1996; 271 (15): 8556-8563.

Wen D, Corina K, Chow EP, Miller S, Janmey PA, Pepinsky RB. The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure. Biochemistry Jul 30 1996; 35 (30): 9700-9709.

Cunningham CC, Leclerc N, Flanagan LA, Lu M, Janmey PA, Kosik KS. Microtubule-associated protein 2c reorganizes both microtubules and microfilaments into distinct cytological structures in an actin-binding protein-280-deficient melanoma cell line. J Cell Biol Feb 24 1997; 136 (4): 845-857.

Flanagan LA, Cunningham CC, Chen J, Prestwich GD, Kosik KS, Janmey PA. The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau. Biophys J Sep 1997; 73 (3): 1440-1447.

Fujita H, Allen PG, Janmey PA, Azuma T, Kwiatkowski DJ, Stossel TP, Furu-uchi K, Kuzumaki N. Characterization of gelsolin truncates that inhibit actin depolymerization by severing activity of gelsolin and cofilin. Eur J Biochem Sep 15 1997; 248 (3): 834-839.

Mahoney NM, Janmey PA, Almo SC. Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation. Nat Struct Biol Nov 1997; 4 (11): 953-960.

Tang JX, Ito T, Tao T, Traub P, Janmey PA. Opposite effects of electrostatics and steric exclusion on bundle formation by F-actin and other filamentous polyelectrolytes. Biochemistry Oct 14 1997; 36 (41): 12600-12607.

Tang JX, Szymanski PT, Janmey PA, Tao T. Electrostatic effects of smooth muscle calponin on actin assembly. Eur J Biochem Jul 1 1997; 247 (1): 432-440.

Glogauer M, Arora P, Chou D, Janmey PA, Downey GP, McCulloch CA. The role of actin-binding protein 280 in integrin-dependent mechanoprotection. J Biol Chem Jan 16 1998; 273 (3): 1689-1698.

Gou JP, Gotow T, Janmey PA, Leterrier JF. Regulation of neurofilament interactions in vitro by natural and synthetic polypeptides sharing Lys-Ser-Pro sequences with the heavy neurofilament subunit NF-H: neurofilament crossbridging by antiparallel sidearm overlapping. Med Biol Eng Comput May 1998; 36 (3): 371-387.

Hubner S, Couvillon AD, Kas JA, Bankaitis VA, Vegners R, Carpenter CL, Janmey PA. Enhancement of phosphoinositide 3-kinase (PI 3-kinase) activity by membrane curvature and inositol-phospholipid-binding peptides. Eur J Biochem Dec 1 1998; 258 (2): 846-853.

Janmey PA. The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiol Rev Jul 1998; 78 (3): 763-781.

Janmey PA, Kas J, Shah JV, Allen PG, Tang JX. Cytoskeletal networks and filament bundles: regulation by proteins and polycations. Biol Bull Jun 1998; 194 (3): 334-335; discussion 335-336.

Janmey PA, Shah JV, Janssen KP, Schliwa M. Viscoelasticity of intermediate filament networks. Subcell Biochem 1998; 31 381-397.

Janmey PA, Stossel TP, Allen PG. Deconstructing gelsolin: identifying sites that mimic or alter binding to actin and phosphoinositides. Chem Biol Apr 1998; 5 (4): R81-85.

Ma L, Cantley LC, Janmey PA, Kirschner MW. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J Cell Biol Mar 9 1998; 140 (5): 1125-1136.

Shah JV, Wang LZ, Traub P, Janmey PA. Interaction of vimentin with actin and phospholipids. Biol Bull Jun 1998; 194 (3): 402-405.

Tang JX, Janmey PA. Two distinct mechanisms of actin bundle formation. Biol Bull Jun 1998; 194 (3): 406-408.

Wriggers W, Tang JX, Azuma T, Marks PW, Janmey PA. Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol Oct 9 1998; 282 (5): 921-932.

Xu J, Schwarz WH, Kas JA, Stossel TP, Janmey PA, Pollard TD. Mechanical properties of actin filament networks depend on preparation, polymerization conditions, and storage of actin monomers. Biophys J May 1998; 74 (5): 2731-2740.

Arora PD, Janmey PA, McCulloch CA. A role for gelsolin in stress fiber-dependent cell contraction. Exp Cell Res Jul 10 1999; 250 (1): 155-167.

Fujita H, Allen PG, Janmey PA, Azuma T, Kwiatkowski DJ, Stossel TP, Kuzumaki N. Induction of apoptosis by gelsolin truncates. Ann N Y Acad Sci 1999; 886 217-220.

Janmey PA, Xian W, Flanagan LA. Controlling cytoskeleton structure by phosphoinositide-protein interactions: phosphoinositide binding protein domains and effects of lipid packing. Chem Phys Lipids Aug 1999; 101 (1): 93-107.

Stock A, Steinmetz MO, Janmey PA, Aebi U, Gerisch G, Kammerer RA, Weber I, Faix J. Domain analysis of cortexillin I: actin-bundling, PIP(2)-binding and the rescue of cytokinesis. Embo J Oct 1 1999; 18 (19): 5274-5284.

Stossel TP, Hartwig JH, Janmey PA, Kwiatkowski DJ. Cell crawling two decades after Abercrombie. Biochem Soc Symp 1999; 65 267-280.

Tang JX, Janmey PA, Stossel TP, Ito T. Thiol oxidation of actin produces dimers that enhance the elasticity of the F-actin network. Biophys J Apr 1999; 76 (4): 2208-2215.

Tuominen EK, Holopainen JM, Chen J, Prestwich GD, Bachiller PR, Kinnunen PK, Janmey PA. Fluorescent phosphoinositide derivatives reveal specific binding of gelsolin and other actin regulatory proteins to mixed lipid bilayers. Eur J Biochem Jul 1999; 263 (1): 85-92.

Xian W, Tang JX, Janmey PA, Braunlin WH. The polyelectrolyte behavior of actin filaments: a 25Mg NMR study. Biochemistry Jun 1 1999; 38 (22): 7219-7226.

Yao L, Janmey P, Frigeri LG, Han W, Fujita J, Kawakami Y, Apgar JR, Kawakami T. Pleckstrin homology domains interact with filamentous actin. J Biol Chem Jul 9 1999; 274 (28): 19752-19761.

Fenteany G, Janmey PA, Stossel TP. Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr Biol Jul 13 2000; 10 (14): 831-838.

Shah JV, Flanagan LA, Janmey PA, Leterrier JF. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol Biol Cell Oct 2000; 11 (10): 3495-3508.

Wang LZ, Gorlin J, Michaud SE, Janmey PA, Goddeau RP, Kuuse R, Uibo R, Adams D, Sawyer ES. Purification of salmon clotting factors and their use as tissue sealants. Thromb Res Dec 15 2000; 100 (6): 537-548.

Wong GC, Tang JX, Lin A, Li Y, Janmey PA, Safinya CR. Hierarchical self-assembly of F-actin and cationic lipid complexes: stacked three-layer tubule networks. Science Jun 16 2000; 288 (5473): 2035-2039.

Bucki R, Janmey PA, Vegners R, Giraud F, Sulpice JC. Involvement of phosphatidylinositol 4,5-bisphosphate in phosphatidylserine exposure in platelets: use of a permeant phosphoinositide-binding peptide. Biochemistry Dec 25 2001; 40 (51): 15752-15761.

Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem Nov 16 2001; 276 (46): 43390-43399.

Foster WJ, Jr., Janmey PA. The distribution of polyphosphoinositides in lipid films. Biophys Chem Jul 24 2001; 91 (3): 211-218.

Janmey PA. Creating a niche in the cytoskeleton: Actin reorganization by a protein kinase. Proc Natl Acad Sci U S A Dec 18 2001; 98 (26): 14745-14747.

Janmey PA, Shah JV, Tang JX, Stossel TP. Actin filament networks. Results Probl Cell Differ 2001; 32 181-199.

Tang JX, Kas JA, Shah JV, Janmey PA. Counterion-induced actin ring formation. Eur Biophys J Dec 2001; 30 (7): 477-484.

Teesalu K, Uibo O, Kalkkinen N, Janmey P, Uibo R. Increased levels of IgA antibodies against desmin in children with coeliac disease. Int Arch Allergy Immunol Oct 2001; 126 (2): 157-166.

Wang Q, Chiang ET, Lim M, Lai J, Rogers R, Janmey PA, Shepro D, Doerschuk CM. Changes in the biomechanical properties of neutrophils and endothelial cells during adhesion. Blood Feb 1 2001; 97 (3): 660-668.

Aranda-Espinoza H, Carl P, Leterrier JF, Janmey P, Discher DE. Domain unfolding in neurofilament sidearms: effects of phosphorylation and ATP. FEBS Lett Nov 20 2002; 531 (3): 397-401.

Flanagan LA, Ju YE, Marg B, Osterfield M, Janmey PA. Neurite branching on deformable substrates. Neuroreport Dec 20 2002; 13 (18): 2411-2415.

Guttman JA, Janmey P, Vogl AW. Gelsolin–evidence for a role in turnover of junction-related actin filaments in Sertoli cells. J Cell Sci Feb 1 2002; 115 (Pt 3): 499-505.

Michaud SE, Wang LZ, Korde N, Bucki R, Randhawa PK, Pastore JJ, Falet H, Hoffmeister K, Kuuse R, Uibo R, Herod J, Sawyer E, Janmey PA. Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants. Thromb Res Sep 1 2002; 107 (5): 245-254.

Nakamura F, Osborn E, Janmey PA, Stossel TP. Comparison of filamin A-induced cross-linking and Arp2/3 complex-mediated branching on the mechanics of actin filaments. J Biol Chem Mar 15 2002; 277 (11): 9148-9154.

Rando OJ, Zhao K, Janmey P, Crabtree GR. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex. Proc Natl Acad Sci U S A Mar 5 2002; 99 (5): 2824-2829.

Tang JX, Janmey PA, Lyubartsev A, Nordenskiold L. Metal ion-induced lateral aggregation of filamentous viruses fd and M13. Biophys J Jul 2002; 83 (1): 566-581.

Xian W, Janmey PA. Dissecting the gelsolin-polyphosphoinositide interaction and engineering of a polyphosphoinositide-sensitive gelsolin C-terminal half protein. J Mol Biol Sep 27 2002; 322 (4): 755-771.

Bucki R, Pastore JJ, Giraud F, Sulpice JC, Janmey PA. Flavonoid inhibition of platelet procoagulant activity and phosphoinositide synthesis. J Thromb Haemost Aug 2003; 1 (8): 1820-1828.

Kiselar JG, Janmey PA, Almo SC, Chance MR. Structural analysis of gelsolin using synchrotron protein footprinting. Mol Cell Proteomics Oct 2003; 2 (10): 1120-1132.

Kiselar JG, Janmey PA, Almo SC, Chance MR. Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proc Natl Acad Sci U S A Apr 1 2003; 100 (7): 3942-3947.

Liepina I, Czaplewski C, Janmey P, Liwo A. Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate. Biopolymers 2003; 71 (1): 49-70.

Lifshitz J, Friberg H, Neumar RW, Raghupathi R, Welsh FA, Janmey P, Saatman KE, Wieloch T, Grady MS, McIntosh TK. Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus. J Cereb Blood Flow Metab Feb 2003; 23 (2): 219-231.

Wagner OI, Lifshitz J, Janmey PA, Linden M, McIntosh TK, Leterrier JF. Mechanisms of mitochondria-neurofilament interactions. J Neurosci Oct 8 2003; 23 (27): 9046-9058.

Weiner DJ, Bucki R, Janmey PA. The antimicrobial activity of the cathelicidin LL37 is inhibited by F-actin bundles and restored by gelsolin. Am J Respir Cell Mol Biol Jun 2003; 28 (6): 738-745.

Wong GC, Lin A, Tang JX, Li Y, Janmey PA, Safinya CR. Lamellar phase of stacked two-dimensional rafts of actin filaments. Phys Rev Lett Jul 4 2003; 91 (1): 018103.

Yin HL, Janmey PA. Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol 2003; 65 761-789.

Bucki R, Pastore JJ, Randhawa P, Vegners R, Weiner DJ, Janmey PA. Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin. Antimicrob Agents Chemother May 2004; 48 (5): 1526-1533.

Dogic Z, Zhang J, Lau AW, Aranda-Espinoza H, Dalhaimer P, Discher DE, Janmey PA, Kamien RD, Lubensky TC, Yodh AG. Elongation and fluctuations of semiflexible polymers in a nematic solvent. Phys Rev Lett Mar 26 2004; 92 (12): 125503.

Forgacs G, Yook SH, Janmey PA, Jeong H, Burd CG. Role of the cytoskeleton in signaling networks. J Cell Sci Jun 1 2004; 117 (Pt 13): 2769-2775.

Fu H, Bjorkman L, Janmey P, Karlsson A, Karlsson J, Movitz C, Dahlgren C. The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide. BMC Cell Biol 2004; 5 (1): 50.

Funaki M, Randhawa P, Janmey PA. Separation of insulin signaling into distinct GLUT4 translocation and activation steps. Mol Cell Biol Sep 2004; 24 (17): 7567-7577.

Hough LA, Islam MF, Janmey PA, Yodh AG. Viscoelasticity of single wall carbon nanotube suspensions. Phys Rev Lett Oct 15 2004; 93 (16): 168102.

Janmey PA, Discher DE. Developmental biology: holding it together in the eye. Nature Oct 7 2004; 431 (7009): 635-636.

Janmey PA, Lindberg U. Cytoskeletal regulation: rich in lipids. Nat Rev Mol Cell Biol Aug 2004; 5 (8): 658-666.

Janmey PA, Weitz DA. Dealing with mechanics: mechanisms of force transduction in cells. Trends Biochem Sci Jul 2004; 29 (7): 364-370.

Liepina I, Janmey P, Czaplewski C, Liwo A. Towards gelsolin amyloid formation. Biopolymers 2004; 76 (6): 543-548.

Nielsen H, Hvidt S, Sheils CA, Janmey PA. Elastic contributions dominate the viscoelastic properties of sputum from cystic fibrosis patients. Biophys Chem Dec 20 2004; 112 (2-3): 193-200.

Rajasalu T, Teesalu K, Janmey PA, Uibo R. Demonstration of natural autoantibodies against the neurofilament protein alpha-internexin in sera of patients with endocrine autoimmunity and healthy individuals. Immunol Lett Jun 15 2004; 94 (1-2): 153-160.

Wagner OI, Ascano J, Tokito M, Leterrier JF, Janmey PA, Holzbaur EL. The interaction of neurofilaments with the microtubule motor cytoplasmic dynein. Mol Biol Cell Nov 2004; 15 (11): 5092-5100.

Wang YL, Burridge K, Dembo M, Gabbiani G, Hanks SK, Hosoya H, Janmey P, Karlsson R, Lindberg U, Mabuchi I, Otey C, Rottner K, Small JV, Wang CL, Zigmond S. Biomedical research publication system. Science Mar 26 2004; 303 (5666): 1974-1976.

Arora PD, Chan MW, Anderson RA, Janmey PA, McCulloch CA. Separate functions of gelsolin mediate sequential steps of collagen phagocytosis. Mol Biol Cell Nov 2005; 16 (11): 5175-5190.

Bucki R, Georges PC, Espinassous Q, Funaki M, Pastore JJ, Chaby R, Janmey PA. Inactivation of endotoxin by human plasma gelsolin. Biochemistry Jul 19 2005; 44 (28): 9590-9597.

Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science Nov 18 2005; 310 (5751): 1139-1143.

Georges PC, Janmey PA. Cell type-specific response to growth on soft materials. J Appl Physiol (1985) Apr 2005; 98 (4): 1547-1553.

Pastore JJ, Funaki M, Janmey PA, Bucki R. Flavonoid-mediated inhibition of actin polymerization in cold-activated platelets. Platelets Sep 2005; 16 (6): 362-367.

Rothwell SW, Reid TJ, Dorsey J, Flournoy WS, Bodo M, Janmey PA, Sawyer E. A salmon thrombin-fibrin bandage controls arterial bleeding in a swine aortotomy model. J Trauma Jul 2005; 59 (1): 143-149.

Storm C, Pastore JJ, MacKintosh FC, Lubensky TC, Janmey PA. Nonlinear elasticity in biological gels. Nature May 12 2005; 435 (7039): 191-194.

Tang JX, Wen Q, Bennett A, Kim B, Sheils CA, Bucki R, Janmey PA. Anionic poly(amino acid)s dissolve F-actin and DNA bundles, enhance DNase activity, and reduce the viscosity of cystic fibrosis sputum. Am J Physiol Lung Cell Mol Physiol Oct 2005; 289 (4): L599-605.

Vijayan K, Discher DE, Lal J, Janmey P, Goulian M. Interactions of membrane-active peptides with thick, neutral, nonzwitterionic bilayers. J Phys Chem B Aug 4 2005; 109 (30): 14356-14364.

Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton Jan 2005; 60 (1): 24-34.

Bucki R, Janmey PA. Interaction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranes. Antimicrob Agents Chemother Sep 2006; 50 (9): 2932-2940.

Bucki R, Pastore JJ, Giraud F, Janmey PA, Sulpice JC. Involvement of the Na+/H+ exchanger in membrane phosphatidylserine exposure during human platelet activation. Biochim Biophys Acta Feb 2006; 1761 (2): 195-204.

Cebers A, Dogic Z, Janmey PA. Counterion-mediated attraction and kinks on loops of semiflexible polyelectrolyte bundles. Phys Rev Lett Jun 23 2006; 96 (24): 247801.

Funaki M, DiFransico L, Janmey PA. PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes. Biochim Biophys Acta Aug 2006; 1763 (8): 889-899.

Georges PC, Miller WJ, Meaney DF, Sawyer ES, Janmey PA. Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. Biophys J Apr 15 2006; 90 (8): 3012-3018.

Janmey PA, Kinnunen PK. Biophysical properties of lipids and dynamic membranes. Trends Cell Biol Oct 2006; 16 (10): 538-546.

Laidmae I, McCormick ME, Herod JL, Pastore JJ, Salum T, Sawyer ES, Janmey PA, Uibo R. Stability, sterility, coagulation, and immunologic studies of salmon coagulation proteins with potential use for mammalian wound healing and cell engineering. Biomaterials Dec 2006; 27 (34): 5771-5779.

Lifshitz J, Janmey PA, McIntosh TK. Photon correlation spectroscopy of brain mitochondrial populations: application to traumatic brain injury. Exp Neurol Feb 2006; 197 (2): 318-329.

Lu YB, Franze K, Seifert G, Steinhauser C, Kirchhoff F, Wolburg H, Guck J, Janmey P, Wei EQ, Kas J, Reichenbach A. Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci U S A Nov 21 2006; 103 (47): 17759-17764.

Sengupta K, Aranda-Espinoza H, Smith L, Janmey P, Hammer D. Spreading of neutrophils: from activation to migration. Biophys J Dec 15 2006; 91 (12): 4638-4648.

Wyss HM, Henderson JM, Byfield FJ, Bruggeman LA, Ding Y, Huang C, Suh JH, Franke T, Mele E, Pollak MR, Miner JH, Janmey PA, Weitz DA, Miller RT. Biophysical properties of normal and diseased renal glomeruli. Am J Physiol Cell Physiol Mar 2006; 300 (3): C397-405.

Bucki R, Byfield FJ, Janmey PA. Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputum. Eur Respir J Apr 2007; 29 (4): 624-632.

Bucki R, Sostarecz AG, Byfield FJ, Savage PB, Janmey PA. Resistance of the antibacterial agent ceragenin CSA-13 to inactivation by DNA or F-actin and its activity in cystic fibrosis sputum. J Antimicrob Chemother Sep 2007; 60 (3): 535-545.

El Sayegh TY, Arora PD, Ling K, Laschinger C, Janmey PA, Anderson RA, McCulloch CA. Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions. Mol Biol Cell Aug 2007; 18 (8): 3026-3038.

Erglis K, Wen Q, Ose V, Zeltins A, Sharipo A, Janmey PA, Cebers A. Dynamics of magnetotactic bacteria in a rotating magnetic field. Biophys J Aug 15 2007; 93 (4): 1402-1412.

Georges PC, Hui JJ, Gombos Z, McCormick ME, Wang AY, Uemura M, Mick R, Janmey PA, Furth EE, Wells RG. Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol Dec 2007; 293 (6): G1147-1154.

Janmey PA, Georges PC, Hvidt S. Basic rheology for biologists. Methods Cell Biol 2007; 83 3-27.

Janmey PA, McCormick ME, Rammensee S, Leight JL, Georges PC, MacKintosh FC. Negative normal stress in semiflexible biopolymer gels. Nat Mater Jan 2007; 6 (1): 48-51.

Janmey PA, McCulloch CA. Cell mechanics: integrating cell responses to mechanical stimuli. Annu Rev Biomed Eng 2007; 9 1-34.

Ju YE, Janmey PA, McCormick ME, Sawyer ES, Flanagan LA. Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels. Biomaterials Apr 2007; 28 (12): 2097-2108.

Kandow CE, Georges PC, Janmey PA, Beningo KA. Polyacrylamide hydrogels for cell mechanics: steps toward optimization and alternative uses. Methods Cell Biol 2007; 83 29-46.

Rammensee S, Janmey PA, Bausch AR. Mechanical and structural properties of in vitro neurofilament hydrogels. Eur Biophys J Jul 2007; 36 (6): 661-668.

Solon J, Levental I, Sengupta K, Georges PC, Janmey PA. Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J Dec 15 2007; 93 (12): 4453-4461.

Tandon R, Levental I, Huang C, Byfield FJ, Ziembicki J, Schelling JR, Bruggeman LA, Sedor JR, Janmey PA, Miller RT. HIV infection changes glomerular podocyte cytoskeletal composition and results in distinct cellular mechanical properties. Am J Physiol Renal Physiol Feb 2007; 292 (2): F701-710.

Wagner OI, Rammensee S, Korde N, Wen Q, Leterrier JF, Janmey PA. Softness, strength and self-repair in intermediate filament networks. Exp Cell Res Jun 10 2007; 313 (10): 2228-2235.

Zhang L, Mao YS, Janmey PA, Yin HL. Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton. Subcell Biochem 2007; 59 177-215.

Bucki R, Byfield FJ, Kulakowska A, McCormick ME, Drozdowski W, Namiot Z, Hartung T, Janmey PA. Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. J Immunol Oct 1 2008; 181 (7): 4936-4944.

Bucki R, Levental I, Kulakowska A, Janmey PA. Plasma gelsolin: function, prognostic value, and potential therapeutic use. Curr Protein Pept Sci Dec 2008; 9 (6): 541-551.

Bucki R, Namiot DB, Namiot Z, Savage PB, Janmey PA. Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13. J Antimicrob Chemother Aug 2008; 62 (2): 329-335.

Heinrich MC, Levental I, Gelman H, Janmey PA, Baumgart T. Critical exponents for line tension and dipole density difference from lipid monolayer domain boundary fluctuations. J Phys Chem B Jul 10 2008; 112 (27): 8063-8068.

Janmey PA, Schliwa M. Rheology. Curr Biol Aug 5 2008; 18 (15): R639-R641.

Kulakowska A, Drozdowski W, Sadzynski A, Bucki R, Janmey PA. Gelsolin concentration in cerebrospinal fluid from patients with multiple sclerosis and other neurological disorders. Eur J Neurol Jun 2008; 15 (6): 584-588.

Levental I, Cebers A, Janmey PA. Combined electrostatics and hydrogen bonding determine intermolecular interactions between polyphosphoinositides. J Am Chem Soc Jul 16 2008; 130 (28): 9025-9030.

Levental I, Janmey PA, Cebers A. Electrostatic contribution to the surface pressure of charged monolayers containing polyphosphoinositides. Biophys J Aug 2008; 95 (3): 1199-1205.

Ma Z, Janmey PA, Finkel TH. The receptor deformation model of TCR triggering. Faseb J Apr 2008; 22 (4): 1002-1008.

Ma Z, Sharp KA, Janmey PA, Finkel TH. Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol Feb 2008; 6 (2): e43.

Weitz DA, Janmey PA. The soft framework of the cellular machine. Proc Natl Acad Sci U S A Jan 29 2008; 105 (4): 1105-1106.

Byfield FJ, Wen Q, Levental I, Nordstrom K, Arratia PE, Miller RT, Janmey PA. Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin. Biophys J Jun 17 2009; 96 (12): 5095-5102.

Chopra A, Tabdanov E, Botta GP, Kresh JY, Janmey P. N-cadherin Mediated Mechanosensitivity and Its Role in Myocyte Cytoskeleton Remodeling. Circulation Nov 3 2009; 120 (18): S775-S775.

Christian DA, Tian A, Ellenbroek WG, Levental I, Rajagopal K, Janmey PA, Liu AJ, Baumgart T, Discher DE. Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nat Mater Oct 2009; 8 (10): 843-849.

Cohen TS, Bucki R, Rosenberg B, Ciccarelli N, Janmey PA, Margulies SS. Gelsolin Treatment Reduces Morbidity with Sepsis.. American Journal of Respiratory and Critical Care Medicine 2009; 179

Discher D, Dong C, Fredberg JJ, Guilak F, Ingber D, Janmey P, Kamm RD, Schmid-Schonbein GW, Weinbaum S. Biomechanics: cell research and applications for the next decade. Ann Biomed Eng May 2009; 37 (5): 847-859.

Franze K, Gerdelmann J, Weick M, Betz T, Pawlizak S, Lakadamyali M, Bayer J, Rillich K, Gogler M, Lu YB, Reichenbach A, Janmey P, Kas J. Neurite branch retraction is caused by a threshold-dependent mechanical impact. Biophys J Oct 7 2009; 97 (7): 1883-1890.

Janmey PA, Winer JP, Murray ME, Wen Q. The hard life of soft cells. Cell Motil Cytoskeleton Aug 2009; 66 (8): 597-605.

Janmey PA, Winer JP, Weisel JW. Fibrin gels and their clinical and bioengineering applications. J R Soc Interface Jan 6 2009; 6 (30): 1-10.

Kang H, Wen Q, Janmey PA, Tang JX, Conti E, MacKintosh FC. Nonlinear elasticity of stiff filament networks: strain stiffening, negative normal stress, and filament alignment in fibrin gels. J Phys Chem B Mar 26 2009; 113 (12): 3799-3805.

Klein EA, Yin L, Kothapalli D, Castagnino P, Byfield FJ, Xu T, Levental I, Hawthorne E, Janmey PA, Assoian RK. Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening. Curr Biol Sep 29 2009; 19 (18): 1511-1518.

Leszczynska K, Namiot A, Fein DE, Wen Q, Namiot Z, Savage PB, Diamond S, Janmey PA, Bucki R. Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice. BMC Microbiol 2009; 9 187.

Leterrier JF, Janmey PA, Eyer J. Microtubule-independent regulation of neurofilament interactions in vitro by neurofilament-bound ATPase activities. Biochem Biophys Res Commun Jun 19 2009; 384 (1): 37-42.

Leterrier JF, Kurachi M, Tashiro T, Janmey PA. MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP. Eur Biophys J Apr 2009; 38 (4): 381-393.

Levental I, Byfield FJ, Chowdhury P, Gai F, Baumgart T, Janmey PA. Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles. Biochem J Dec 1 2009; 424 (2): 163-167.

Levental I, Christian DA, Wang YH, Madara JJ, Discher DE, Janmey PA. Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry Sep 1 2009; 48 (34): 8241-8248.

Miller WJ, Leventhal I, Scarsella D, Haydon PG, Janmey P, Meaney DF. Mechanically induced reactive gliosis causes ATP-mediated alterations in astrocyte stiffness. J Neurotrauma May 2009; 26 (5): 789-797.

Papasavvas E, Pistilli M, Reynolds G, Bucki R, Azzoni L, Chehimi J, Janmey PA, DiNubile MJ, Ondercin J, Kostman JR, Mounzer KC, Montaner LJ. Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1-infected patients. Aids Jan 28 2009; 23 (3): 369-375.

Randazzo RA, Bucki R, Janmey PA, Diamond SL. A series of cationic sterol lipids with gene transfer and bactericidal activity. Bioorg Med Chem May 1 2009; 17 (9): 3257-3265.

Rothwell SW, Sawyer E, Dorsey J, Flournoy WS, Settle T, Simpson D, Cadd G, Janmey P, White C, Szabo KA. Wound healing and the immune response in swine treated with a hemostatic bandage composed of salmon thrombin and fibrinogen. J Mater Sci Mater Med Oct 2009; 20 (10): 2155-2166.

Talja I, Reimand T, Uibo O, Reimand K, Aun S, Talvik T, Janmey PA, Uibo R. Antibodies to neurofilaments. Ann N Y Acad Sci Sep 2009; 1173 130-136.

Talja I, Reimand T, Uibo O, Reimand K, Aun S, Talvik T, Janmey PA, Uibo R. Antibodies to Neurofilaments Clinical and Immunogenetic Associations in Down Syndrome. Contemporary Challenges in Autoimmunity 2009; 1173 130-136.

Tee SY, Bausch AR, Janmey PA. The mechanical cell. Curr Biol Sep 15 2009; 19 (17): R745-748.

Uibo R, Laidmae I, Sawyer ES, Flanagan LA, Georges PC, Winer JP, Janmey PA. Soft materials to treat central nervous system injuries: evaluation of the suitability of non-mammalian fibrin gels. Biochim Biophys Acta May 2009; 1793 (5): 924-930.

Winer JP, Janmey PA, McCormick ME, Funaki M. Bone marrow-derived human mesenchymal stem cells become quiescent on soft substrates but remain responsive to chemical or mechanical stimuli. Tissue Eng Part A Jan 2009; 15 (1): 147-154.

Winer JP, Oake S, Janmey PA. Non-linear elasticity of extracellular matrices enables contractile cells to communicate local position and orientation. PLoS One 2009; 4 (7): e6382.

Bucki R, Kulakowska A, Byfield FJ, Zendzian-Piotrowska M, Baranowski M, Marzec M, Winer JP, Ciccarelli NJ, Gorski J, Drozdowski W, Bittman R, Janmey PA. Plasma gelsolin modulates cellular response to sphingosine 1-phosphate. Am J Physiol Cell Physiol Dec 2010; 299 (6): C1516-1523.

Bucki R, Leszczynska K, Byfield FJ, Fein DE, Won E, Cruz K, Namiot A, Kulakowska A, Namiot Z, Savage PB, Diamond SL, Janmey PA. Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Antimicrob Agents Chemother Jun 2010; 54 (6): 2525-2533.

Chen DTN, Wen Q, Janmey PA, Crocker JC, Yodh AG. Rheology of Soft Materials. Annual Review of Condensed Matter Physics, Vol 1 2010; 1 301-322.

Chopra A, Lin V, McCollough A, Atzet S, Prestwich GD, Wechsler AS, Janmey PA, Kresh JY. Engineered Extracellular Matrix Bioactivity and Mechanics Modulate Cardiac Myocyte Phenotype. Circulation Nov 23 2010; 122 (21):

Fein DE, Bucki R, Byfield F, Leszczynska K, Janmey PA, Diamond SL. Novel cationic lipids with enhanced gene delivery and antimicrobial activity. Mol Pharmacol Sep 2010; 78 (3): 402-410.

Kulakowska A, Ciccarelli NJ, Wen Q, Mroczko B, Drozdowski W, Szmitkowski M, Janmey PA, Bucki R. Hypogelsolinemia, a disorder of the extracellular actin scavenger system, in patients with multiple sclerosis. BMC Neurol 2010; 10 107.

Laidmae I, Salum T, Sawyer ES, Janmey PA, Uibo R. Characterization of the biological effect of fish fibrin glue in experiments on rats: immunological and coagulation studies. J Biomed Mater Res A Apr 2010; 93 (1): 29-36.

Leszczynska K, Namiot A, Janmey PA, Bucki R. Modulation of exogenous antibiotic activity by host cathelicidin LL-37. Apmis Nov 2010; 118 (11): 830-836.

Levental I, Levental KR, Klein EA, Assoian R, Miller RT, Wells RG, Janmey PA. A simple indentation device for measuring micrometer-scale tissue stiffness. J Phys Condens Matter May 19 2010; 22 (19): 194120.

Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell Dec 10 2010; 143 (6): 966-977.

Rasi K, Piuhola J, Czabanka M, Sormunen R, Ilves M, Leskinen H, Rysa J, Kerkela R, Janmey P, Heljasvaara R, Peuhkurinen K, Vuolteenaho O, Ruskoaho H, Vajkoczy P, Pihlajaniemi T, Eklund L. Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy. Circ Res Nov 12 2010; 107 (10): 1241-1252.

Rothwell SW, Settle T, Wallace S, Dorsey J, Simpson D, Bowman JR, Janmey P, Sawyer E. The long term immunological response of swine after two exposures to a salmon thrombin and fibrinogen hemostatic bandage. Biologicals Nov 2010; 38 (6): 619-628.

Arora PD, Wang Y, Janmey PA, Bresnick A, Yin HL, McCulloch CA. Gelsolin and non-muscle myosin IIA interact to mediate calcium-regulated collagen phagocytosis. J Biol Chem Sep 30 2011; 286 (39): 34184-34198.

Basu A, Wen Q, Mao XM, Lubensky TC, Janmey PA, Yodh AG. Nonaffine Displacements in Flexible Polymer Networks. Macromolecules Mar 22 2011; 44 (6): 1671-1679.

Byfield FJ, Kowalski M, Cruz K, Leszczynska K, Namiot A, Savage PB, Bucki R, Janmey PA. Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa. J Immunol Dec 15 2011; 187 (12): 6402-6409.

Byfield FJ, Wen Q, Leszczynska K, Kulakowska A, Namiot Z, Janmey PA, Bucki R. Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability. Am J Physiol Cell Physiol Jan 2011; 300 (1): C105-112.

Byfield FJ, Wen Q, Tee SY, Janmey PA. Driving cytoskeletal remodeling by extracellular matrix mechanics. European Biophysics Journal with Biophysics Letters Aug 2011; 40 160-160.

Chopra A, Patel A, Janmey P, Kresh JY. Contractility dependent regulation of the N-cadherin complex formation and myocyte structural organization. Faseb Journal Apr 2011; 25

Chopra A, Tabdanov E, Patel H, Janmey PA, Kresh JY. Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing. Am J Physiol Heart Circ Physiol Apr 2011; 300 (4): H1252-1266.

Cohen TS, Bucki R, Byfield FJ, Ciccarelli NJ, Rosenberg B, DiNubile MJ, Janmey PA, Margulies SS. Therapeutic potential of plasma gelsolin administration in a rat model of sepsis. Cytokine Jun 2011; 54 (3): 235-238.

Ellenbroek WG, Wang YH, Christian DA, Discher DE, Janmey PA, Liu AJ. Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers. Biophys J Nov 2 2011; 101 (9): 2178-2184.

Huisman EM, Wen Q, Wang YH, Cruz K, Kitenbergs G, Erglis K, Zeltins A, Cebers A, Janmey PA. Gelation of semiflexible polyelectrolytes by multivalent counterions. Soft Matter Aug 21 2011; 7 (16): 7257-7261.

Janmey PA, Miller RT. Mechanisms of mechanical signaling in development and disease. J Cell Sci Jan 1 2011; 124 (Pt 1): 9-18.

Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, Janmey PA, Pihlajaniemi T. Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane. J Biol Chem Mar 11 2011; 286 (10): 7755-7764.

Leszczynska K, Namiot A, Cruz K, Byfield FJ, Won E, Mendez G, Sokolowski W, Savage PB, Bucki R, Janmey PA. Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infections. J Appl Microbiol Jan 2011; 110 (1): 229-238.

Lin V, Chopra A, Janmey P, Kresh JY. Hyaluronan Mediates Cardiac Myocyte Phenotypic Response. Faseb Journal Apr 2011; 25

Ma Z, Janmey PA, Sharp KA, Finkel TH. Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation. Microsc Res Tech Dec 2011; 74 (12): 1174-1185.

Mendez M, Wen Q, Janmey P. Vimentin’s Effect on Stiffness Depends on Cell Type. Molecular Biology of the Cell 2011; 22

Morris HS, Bautista T, Bucki R, Savage P, Janmey P, Sostarecz AG. Investigation of the mechanism of action of the synthetic antibiotic CSA-13 using Langmuir monolayers for application in cystic fibrosis treatment. Abstracts of Papers of the American Chemical Society Mar 27 2011; 241

Olsen AL, Bloomer SA, Chan EP, Gaca MD, Georges PC, Sackey B, Uemura M, Janmey PA, Wells RG. Hepatic stellate cells require a stiff environment for myofibroblastic differentiation. Am J Physiol Gastrointest Liver Physiol Jul 2011; 301 (1): G110-118.

Park J, Chopra A, Janmey P, Kresh JY. Changes in cardiac myocyte shape alter transcriptional expression of cell-to-cell junction proteins. Faseb Journal Apr 2011; 25

Slochower DR, Janmey PA. Molecular Dynamics Simulations of Monolayers and Membranes with Phosphatidylinositol Bisphosphate. Biophysical Journal Feb 2 2011; 100 (3): 88-88.

Tee SY, Fu J, Chen CS, Janmey PA. Cell shape and substrate rigidity both regulate cell stiffness. Biophys J Mar 2 2011; 100 (5): L25-27.

Wang YH, Janmey PA. The Competitive Binding of Ca2+ vs. Mg2+ to PIP2-Containing Lipid Monolayers and the Comparison of Pi(4,5)P2 and its Isomers. Biophysical Journal Feb 2 2011; 100 (3): 330-330.

Weisshaar CL, Winer JP, Guarino BB, Janmey PA, Winkelstein BA. The potential for salmon fibrin and thrombin to mitigate pain subsequent to cervical nerve root injury. Biomaterials Dec 2011; 32 (36): 9738-9746.

Wen Q, Byfield FJ, Nordstrom K, Arratia PE, Miller RT, Janmey PA. Loss of an Actin Crosslinker Uncouples Cell Spreading from Cell Stiffening on Gels with a Gradient of Stiffness. Biophysical Journal Feb 2 2011; 100 (3): 443-443.

Wen Q, Janmey PA. Polymer physics of the cytoskeleton. Curr Opin Solid State Mater Sci Oct 1 2011; 15 (5): 177-182.

Chopra A, Lin V, McCollough A, Atzet S, Prestwich GD, Wechsler AS, Murray ME, Oake SA, Kresh JY, Janmey PA. Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors. J Biomech Mar 15 2012; 45 (5): 824-831.

Chopra A, Patel A, Shieh AC, Janmey PA, Kresh JY. alpha-Catenin localization and sarcomere self-organization on N-cadherin adhesive patterns are myocyte contractility driven. PLoS One 2012; 7 (10): e47592.

Davis JT, Wen Q, Janmey PA, Otteson DC, Foster WJ. Muller cell expression of genes implicated in proliferative vitreoretinopathy is influenced by substrate elastic modulus. Invest Ophthalmol Vis Sci 2012; 53 (6): 3014-3019.

Janmey PA, Wen Q, Cebers A. Polyelectrolyte effects in crosslinking of cytoskeletal polymers and filamentous viruses. Abstracts of Papers of the American Chemical Society Aug 19 2012; 244

Kothapalli D, Liu SL, Bae YH, Monslow J, Xu T, Hawthorne EA, Byfield FJ, Castagnino P, Rao S, Rader DJ, Pure E, Phillips MC, Lund-Katz S, Janmey PA, Assoian RK. Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Rep Nov 29 2012; 2 (5): 1259-1271.

Laidmae I, Belozjorova J, Sawyer ES, Janmey PA, Uibo R. Salmon fibrin glue in rats: antibody studies. Biologicals Jan 2012; 40 (1): 55-60.

Mendez MG, Janmey PA. Transcription factor regulation by mechanical stress. Int J Biochem Cell Biol May 2012; 44 (5): 728-732.

Mohammad I, Arora PD, Naghibzadeh Y, Wang Y, Li J, Mascarenhas W, Janmey PA, Dawson JF, McCulloch CA. Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration. Faseb J Aug 2012; 26 (8): 3260-3272.

Seiler C, Davuluri G, Abrams J, Byfield FJ, Janmey PA, Pack M. Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol 2012; 10 (9): e1001386.

Slochower DR, Huwe PJ, Bradley RP, Radhakrishnan R, Janmey PA. Molecular dynamics simulations of ion binding and protonation of phosphatidylinositol bisphosphate (PIP2). Abstracts of Papers of the American Chemical Society Aug 19 2012; 244

Tang X, Wen Q, Kuhlenschmidt TB, Kuhlenschmidt MS, Janmey PA, Saif TA. Attenuation of cell mechanosensitivity in colon cancer cells during in vitro metastasis. PLoS One 2012; 7 (11): e50443.

Wang YH, Collins A, Guo L, Smith-Dupont KB, Gai F, Svitkina T, Janmey PA. Divalent cation-induced cluster formation by polyphosphoinositides in model membranes. J Am Chem Soc Feb 22 2012; 134 (7): 3387-3395.

Wen Q, Basu A, Janmey PA, Yodh AG. Non-affine deformations in polymer hydrogels. Soft Matter Jan 1 2012; 8 (31): 8039-8049.

Arora PD, Wang Y, Bresnick A, Dawson J, Janmey PA, McCulloch CA. Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions. Mol Biol Cell Mar 2013; 24 (6): 734-747.

Ben Aroush DR, Janmey P, Egelhoff T. The Role of Myosin-II in Cell Spreading on Soft Hyaluronan-Fibronectin Substrates. Biophysical Journal Jan 29 2013; 104 (2): 476a-477a.

Bucki R, Cruz K, Janmey P. Dissolution of DNA and F-Actin Bundles Stabilized by Polyelectrolyte Effects. Biophysical Journal Jan 29 2013; 104 (2): 256a-256a.

Franze K, Janmey PA, Guck J. Mechanics in neuronal development and repair. Annu Rev Biomed Eng 2013; 15 227-251.

Janmey PA, Wells RG, Assoian RK, McCulloch CA. From tissue mechanics to transcription factors. Differentiation Oct 2013; 86 (3): 112-120.

Kapus A, Janmey P. Plasma membrane–cortical cytoskeleton interactions: a cell biology approach with biophysical considerations. Compr Physiol Jul 2013; 3 (3): 1231-1281.

Leszczynska K, Namiot D, Byfield FJ, Cruz K, Zendzian-Piotrowska M, Fein DE, Savage PB, Diamond S, McCulloch CA, Janmey PA, Bucki R. Antibacterial activity of the human host defence peptide LL-37 and selected synthetic cationic lipids against bacteria associated with oral and upper respiratory tract infections. J Antimicrob Chemother Mar 2013; 68 (3): 610-618.

Mendez MG, Murray ME, Restle DJ, Janmey PA. Vimentin Filament Assembly is Altered by Substrate Elastic Modulus. Biophysical Journal Jan 29 2013; 104 (2): 141a-141a.

Murray ME, Mendez MG, Janmey PA. Characterization of the Vimentin Intermediate Filament Network on Substrates of Varying Stiffness. Biophysical Journal Jan 29 2013; 104 (2): 478a-478a.

Perepelyuk M, Terajima M, Wang AY, Georges PC, Janmey PA, Yamauchi M, Wells RG. Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury. Am J Physiol Gastrointest Liver Physiol Mar 15 2013; 304 (6): G605-614.

Slochower DR, Huwe PJ, Radhakrishnan R, Janmey PA. Quantum and all-atom molecular dynamics simulations of protonation and divalent ion binding to phosphatidylinositol 4,5-bisphosphate (PIP2). J Phys Chem B Jul 18 2013; 117 (28): 8322-8329.

Smith JR, Syre PP, Oake SA, Nicholson KJ, Weisshaar CL, Cruz K, Bucki R, Baumann BC, Janmey PA, Winkelstein BA. Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1. PLoS One 2013; 8 (11): e80006.

van Oosten AS, Janmey PA. Extremely charged and incredibly soft: physical characterization of the pericellular matrix. Biophys J Mar 5 2013; 104 (5): 961-963.

Wang YH, Janmey PA. Divalent Cation-Induced PIP2 Clustering in Cholesterol-Containing Membranes: How PIP2 Lateral Distribution affects PIP2-Gelsolin Interaction. Biophysical Journal Jan 29 2013; 104 (2): 429a-429a.

Wen Q, Janmey PA. Effects of non-linearity on cell-ECM interactions. Exp Cell Res Oct 1 2013; 319 (16): 2481-2489.

Chopra A, Murray ME, Byfield FJ, Mendez MG, Halleluyan R, Restle DJ, Raz-Ben Aroush D, Galie PA, Pogoda K, Bucki R, Marcinkiewicz C, Prestwich GD, Zarembinski TI, Chen CS, Pure E, Kresh JY, Janmey PA. Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials Jan 2014; 35 (1): 71-82.

Del Campo CM, Mishra AK, Wang YH, Roy CR, Janmey PA, Lambright DG. Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM. Structure Mar 4 2014; 22 (3): 397-408.

Janmey PA, Mackintosh FC. Cytoplasmic transport: bacteria turn to glass unless kicked. Curr Biol Mar 17 2014; 24 (6): R226-228.

Janmey PA, Slochower DR, Wang YH, Wen Q, Cebers A. Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids. Soft Matter Feb 12 2014; 10 (10): 1439-1449.

Mohammadi H, Janmey PA, McCulloch CA. Lateral boundary mechanosensing by adherent cells in a collagen gel system. Biomaterials Jan 2014; 35 (4): 1138-1149.

Murray ME, Mendez MG, Janmey PA. Substrate stiffness regulates solubility of cellular vimentin. Mol Biol Cell Jan 2014; 25 (1): 87-94.

Slochower DR, Wang YH, Tourdot RW, Radhakrishnan R, Janmey PA. Counterion-mediated pattern formation in membranes containing anionic lipids. Adv Colloid Interface Sci Jan 30 2014;

Wang YH, Slochower DR, Janmey PA. Counterion-mediated cluster formation by polyphosphoinositides. Chem Phys Lipids Jan 15 2014;

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