Counterion-mediated pattern formation in membranes containing anionic lipids

A simplified representation of a typical mammalian membrane bilayer composition highlighting common lipid families. Cholesterol is shown on both sides of the bilayer, while the extracellular facing leaflet is shown containing PtdCho (gray); the cytosolic leaflet is shown containing negatively charged PtdSer (orange) and PtdIns(4,5)P2 (red) together with the zwitterionic PtdEtn (cyan). The total amount and ratio of lipid species in various cell types can be found in several sources, including [1], [2] and [3]. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Slochower DR, Wang YH, Tourdot RW, Radhakrishnan R, Janmey PA. Counterion-mediated pattern formation in membranes containing anionic lipids. Adv Colloid Interface Sci Jan 30 2014; Summary Most lipid components of cell membranes are either neutral, like cholesterol, or zwitterionic, like phosphatidylcholine and sphingomyelin. Very few lipids, such as sphingosine, are …

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The Atherosusceptible Endothelium: Endothelial Phenotypes in Complex Haemodynamic Shear Stress Regions in vivo.

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Davies PF, Civelek M, Fang Y, Fleming I. Cardiovasc Res. 2013 Jul 15 Abstract Atherosclerosis initiates at predictable focal sites and develops to a spatially regional disease with limited distribution. There is compelling evidence that links haemodynamics to the localized origin of atherosclerotic lesions. Arterial flow in vivo is unsteady, …

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The Special Dean’s Awards

Peter Davies, Ph.D.

The Special Dean’s Awards, established during the 1989-90 academic year, honor special achievements by Penn faculty members, particularly in the development of new and innovative educational programs. The Vice Dean for Education, in consultation with the Teaching Awards Selection Committee, identifies faculty members who have made unique contributions to medical …

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School of Design Teaching Awards

Jenny Sabin

The G. Holmes Perkins Award for Distinguished Teaching by a member of the associated faculty is awarded to Ms. Jenny Sabin, lecturer in architecture. Ms. Sabin’s research, teaching and design practice focuses on the contextual, material and formal intersections between architecture, textile tectonics and biology. Her design expertise resides in …

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